Gallic Acid hmoov, los yog gallate, yog cov nplua nuj polyphenolic compound uas muaj ntau pawg hydroxyl thiab hydroxy ester hauv nws cov qauv tshuaj. Qhov sib xyaw no feem ntau pom muaj nyob rau hauv cov nroj tsuag xws li tsob ntoo gallnut, oaks, thiab cotoneasters. Gallate feem ntau muaj nyob rau hauv daim ntawv monomeric lossis polymeric. Nws tuaj yeem ua rau lub cev muaj zog, nqhis dej, nres los ntshav, thiab txo qis ntshav.
Kev tshawb fawb tshuaj niaj hnub no qhia tau hais tias nws muaj tshuaj tiv thaiv - mob, tshuaj tua kab mob, tshuaj tua kab mob, tshuaj tua kab mob, thiab lwm yam dej num lom neeg. Nws muaj cov nyhuv inhibitory ntawm Staphylococcus aureus, Pseudomonas aeruginosa, Neisseria, thiab Salmonella typhi. Yog li ntawd, rau cov kab mob xws li kab mob khaub thuas thiab Shigella dysenteriae, gallate kuj tuaj yeem ua haujlwm pab kho mob thiab txo cov tsos mob. Nws muaj lub luag haujlwm tshwj xeeb ntxiv hauv cov kab mob khaub thuas mob ntsws, mob ntsws, mob ntshav qab zib, kab mob plawv, kab mob plawv thiab cerebrovascular, kab mob paj hlwb, thiab lwm yam. Nws kuj yog siv los ua antioxidant thiab preservative hauv cov khoom noj. Nws khaws cov zaub mov tshiab thiab zoo dua los ntawm kev tiv thaiv oxidation thiab microbiological kev loj hlob thiab txuas ntxiv lub neej txee ntawm cov zaub mov. Gallate kuj tseem siv rau hauv brewing thiab npias - ua cov txheej txheem los txhim kho cov khoom saj thiab tiv thaiv kab mob microbial. Nws kuj tseem siv rau hauv kev lag luam tawv los tsim cov xim thiab xim. Nws cov khoom astringent thiab antioxidant ua rau nws muaj txiaj ntsig zoo siv dav hauv cov kev lag luam no.
Shaanxi Medibridge Biotech Co., Ltd., Ltd. muab cov nroj tsuag rho tawm, cov khoom noj khoom haus, thiab cov khoom siv tshwj xeeb rau cov khoom sib txawv thiab kev xav tau. Peb txhawb nqa cov khoom ruaj khov, cov kev qhia tshwj xeeb niaj hnub sib xws, thiab cov kev pabcuam ntim hloov tau yooj yim rau cov khoom xyaw - raws li kev tsim khoom.
COA
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Khoom npe |
CAS Nr |
Batch Number |
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Gallic Acid hmoov |
149-91-7 |
MB2606131445 |
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Hnub tim tsim khoom |
Hnub Soj Ntsuam |
Hnub Kawg |
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2026/6/13 |
2026/6/15 |
2028/6/15 |
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Qauv Qty Puag |
Ntim |
Txoj Kev Xeem |
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100 KGS |
25KG / nruas |
HPLC |
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Yam khoom |
Txuj |
Cov txiaj ntsig |
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Cov cwj pwm / tsos |
Ib tug dawb mus rau beige hmoov |
Dawb hmoov |
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APHA |
180 Max |
170 |
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Solubility (Turbidity) 50mg / ml etoh |
meej |
meej |
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Poob rau ziab |
10% Max |
9.19% |
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Residue ntawm ignition |
0.1% Max |
0.031% |
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Tannic Acid |
1.0 ppm Max |
ua raws |
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Sulfate |
20 ppm Max |
ua raws |
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AS |
3 ppm max |
ua raws |
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turbidity |
10 Max |
ua raws |
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Purity |
99.5% |
99.53% |
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Xaus |
Cov batch ua raws li IN-HOUSE tus qauv |
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Natural Distribution & Biosynthesis
Ntuj tshwm sim
Gallic acid yog dav faib rau hauv cov nroj tsuag siab dua. Nyob rau hauv feem ntau cov nroj tsuag nws tsis muaj nyob raws li ib tug dawb monomer, tab sis yog covalently khi nyob rau hauv hydrolysable tannins (gallotannins) ntawm ester linkages.
- Siab-cov ntsiab lus cog: Suav gallnuts (Rhus chinensis galls), pomegranate rind, sumac.
- Nruab nrab- cov ntsiab lus: tshuaj yej ntsuab, tshuaj yej dub, txiv hmab txiv ntoo thiab noob, walnuts, ntoo qhib tawv, nplooj eucalyptus.
Suav gallnut yog cov khoom siv raw khoom tseem ceeb tshaj plaws, vim nws cov ntsiab lus tannin siab thiab cov khoom ruaj khov.
Biosynthesis hauv cov nroj tsuag
Txoj hauv kev biosynthetic tseem ceeb mus los ntawm txoj kev shikimate . 3-Dehydroshikimate hloov mus rau gallic acid los ntawm dehydrogenase catalysis; Gallic acid yog esterified nrog qabzib los ua gallotannins. Txoj hauv kev no yog lub hom phiaj tshawb fawb tseem ceeb hauv kev tsim cov tshuaj metabolic ntawm tannin - cov nroj tsuag nplua nuj.
Kev Tsim Kho Kev Lag Luam
- Acid hydrolysis ntawm tannic acid (cov txheej txheem lag luam tseem ceeb)
Tannic acid yog muab rho tawm los ntawm gallnuts thiab hydrolyzed nyob rau hauv dilute acid, siab kub thiab siab (133-135 degree, 0.18-0.2 MPa), rhuav lub ester bonds tso tawm gallic acid thiab qabzib. Cov khoom tom qab ntawd tau qhib ua haujlwm -carbon decolorization, recrystallization, pom, ziab thiab milling kom tau txais cov hmoov tiav.
- Qhov zoo: tsawg tus nqi raw khoom, muaj peev xwm ntau lawm.
- Qhov tsis zoo: kev siv hluav taws xob siab, kev kho cov dej khib nyiab tseem ceeb.
- Enzymatic hydrolysis nrog tannase
Tannase catalyzes hydrolysis ntawm tannins nyob rau hauv qhov kub thiab txias thiab ze rau -pH nruab nrab.
- Qhov zoo: tsawg dua qhov tshwm sim, qis impurities, haum rau siab -purity cosmetic thiab kws tshuaj- cov khoom qib.
- Qhov tsis zoo: tus nqi tsim khoom ntau dua, txwv kev hla dhau.
- Tag nrho cov tshuaj synthesis
Tsis tshua muaj siv rau kev tsim khoom loj; ua hauj lwm tsuas yog los tsim cov isotope-labeled gallic acid rau kev tshawb fawb tshuab.
Biological Activities & Molecular Mechanisms
Antioxidant Kev Ua Haujlwm (Core Property)
1. Direct ROS scavenging: neutralizes hydroxyl radicals, superoxide anions thiab peroxynitrite anions. Phenolic hydroxyl pawg pub hydrogen atoms los txiav cov lipid peroxidation saw cov tshuaj tiv thaiv; Qhov tshwm sim phenoxyl radical yog stabilized los ntawm aromatic resonance.
2. Hlau ion chelation: ntes hlau thiab tooj liab ions, inhibits Fenton cov tshuaj tiv thaiv, thiab thaiv hlau -catalyzed oxidative puas.
3. Ua kom muaj Nrf2/ARE antioxidant txoj kev: upregulates endogenous antioxidant proteins xws li SOD, CAT, GSH thiab HO-1, pab txhawb cellular tiv thaiv tus kheej.
Concentration-dependent biphasic effect (tseem ceeb rau kev sim tsim): nyob rau hauv qis concentrations gallic acid ua raws li antioxidant; ntawm qhov siab heev nws tuaj yeem dhau los ua pro-oxidant, inducing ROS tiam thiab ua rau apoptosis. Kev tshuaj xyuas koob tshuaj yuav tsum coj cov khoom no mus rau hauv tus account.
Kev tiv thaiv -kev tswj kev mob
Gallic acid inhibits inflammatory teb los ntawm ntau txoj kev:
- Txhawb nqa NF-κB kev hloov pauv hauv nuclear thiab phosphorylation ntawm MAPKs (p38/ERK/JNK);
- Inhibits los ua ke thiab ua kom cov NLRP3 inflammasome;
- Downregulates pro-cov neeg kho mob inflammatory xws li TNF- , IL-1 , IL-6 , COX-2 thiab iNOS.
Cov tsiaj ntawv luam tawm cov qauv kev tshawb fawb npog ntawm daim tawv nqaij mob, colitis, kab mob siab thiab gouty o.
Antimicrobial Activity
- Antibacterial: inhibits Gram-cov kab mob zoo (xws li Staphylococcus aureus, Listeria monocytogenes) thiab Gram- cov kab mob tsis zoo (xws li E. coli, Salmonella). Mechanisms muaj xws li cuam tshuam ntawm cov kab mob membrane muaj peev xwm, inhibition ntawm biofilm tsim, thiab cuam tshuam nrog lub zog metabolism.
- Antifungal: inhibits dermatophytes thiab Candida hauv vitro.
- Antiviral: ntau yam hauv vitro cov ntaub ntawv qhia tias muaj peev xwm tiv thaiv cov kab mob hauv lub hnab, tab sis hauv vivo validation tsis txaus thiab cov pov thawj tseem nyob ua ntej.
Cov Lus Qhia Txog Kev Tshawb Fawb Tshiab
Hepatoprotection: txo oxidative kev raug mob thiab lipid tsub zuj zuj nyob rau hauv daim siab puas qauv.
Kev tswj hwm metabolic: Txhim kho insulin rhiab heev thiab modulates lipid metabolism hauv cov tsiaj rog rog.
Neuroprotection: inhibits A peptide aggregation thiab txo cov neuronal oxidative kev nyuaj siab, kawm hauv Alzheimer's - kab mob - ntsig txog qauv.
Antimutagenesis thiab tshuaj tiv thaiv kab mob: selectively induces apoptosis hauv ntau kab mob qog noj ntshav hauv.
FAQ
Cov zaub mov twg muaj ntau hauv gallic acid?
Cov zaub mov siab tshaj hauv cov kua qaub muaj xws li qee cov txuj lom, txiv ntoo, tshuaj yej, txiv hmab txiv ntoo, thiab dej haus.
Puas yog gallic acid zoo rau cov tawv nqaij?
Yog lawm, gallic acid yog qhov zoo rau daim tawv nqaij vim nws ua raws li lub zog, maj mam antioxidant uas tiv thaiv ib puag ncig kev ntxhov siab xws li cov pa phem thiab UV rays.
Kuv tuaj yeem tau txais gallic acid nyob qhov twg?
Gallic acid yog cov nroj tsuag ntuj tsim muaj nyob rau hauv ntau ntau hauv cov ntoo qhib ntoo, gallnuts, tshuaj yej nplooj, thiab qee cov txiv hmab txiv ntoo thiab txiv ntoo.
Gallic acid siv rau dab tsi?
Gallic acid yog cov nroj tsuag ntuj siv los ua cov tshuaj tua kab mob antioxidant, cov khoom siv tshuaj, thiab cov khoom lag luam.
Yog tias koj tab tom nrhiav rau siab - zooGallic Acid hmoovcov chaw tsim khoom uas koj tuaj yeem tsim kom muaj sijhawm ntev -, kev sib koom tes ruaj khov, ces Shaanxi Medibridge Biotech Co., Ltd. yuav yog koj tus khub lag luam zoo tshaj plaws. Tsis txhob yig tiv tauj peb ntawmhi@medibridgeapi.com.
Cim npe nrov: Tuam Tshoj gallic acid hmoov manufacturers, lwm tus neeg, Hoobkas
