Genistein hmoov, tseem hu ua differenola, genisteol, genisterin; los yog kheej kheej mas muaj nyob rau hauv leguminous nroj tsuag, xws li Sophora japonica, Sophora japonica, thiab lwm yam. Nws yog ib qho ntawm feem ntau isoflavones nyob rau hauv soybeans thiab yog 7-glucoside ntawm differenola, cov khoom xyaw nquag ntawm soybean isoflavones. Nws kuj yog ib qho ntawm ntau lub npe isoflavones. Isoflavonoid tebchaw xws li differenola thiab daidzein muaj nyob hauv ntau cov nroj tsuag. Txawm li cas los xij, cov ntsiab lus tseem ceeb ntawm cov kua txiv hmab txiv ntoo yog cov khoom xws li taum paj, taum pauv, thiab texturized zaub proteins. Vim nws cov qauv zoo sib xws rau tib neeg cov tshuaj estrogen, nws tseem hu ua phytoestrogens.
Nws inhibits tshwj xeeb tyrosine protein kinases thiab DNA topoisomerase II, cov noob caj noob ces - tsom rau cov tshuaj tiv thaiv kab mob. Ob txoj kev ua enzymes no tuaj yeem tiv thaiv tau ntau txoj hauv kev, suav nrog kev tswj hwm cov noob tsis zoo thiab tiv thaiv cov kab mob ntawm cov kab mob proliferation thiab metastasis. Cov tshuaj ua rau DNA fragmentation thiab apoptosis thiab induces G2/M cell voj voog ntes los ntawm inhibiting topoisomerase-II. Nws muaj txiaj ntsig zoo rau kev noj qab haus huv, suav nrog nws cov tshuaj tiv thaiv - mob thiab cov tshuaj tua kab mob antioxidant, tau txais kev mloog. Genistin yog siv los tswj homocysteine thiab lwm yam tyrosine kinase inhibitors thim rov qab. Nws tuaj yeem txhim kho insulin tsis kam thiab tiv thaiv - mob ntshav qab zib, inhibit kab mob kev ua haujlwm ntawm tes, thiab inhibit prostate cancer thiab kev ua haujlwm antioxidant. Nws extraction muab tshiab raw cov ntaub ntawv thiab functional additives rau cov zaub mov thiab kws industries.
Shaanxi Medibridge Biotech Co., Ltd., Ltd. muab cov nroj tsuag rho tawm, cov khoom noj khoom haus, thiab cov khoom siv tshwj xeeb rau cov khoom sib txawv thiab kev xav tau. Peb txhawb nqa cov khoom ruaj khov, cov kev qhia tshwj xeeb niaj hnub sib xws, thiab cov kev pabcuam ntim hloov tau yooj yim rau cov khoom xyaw - raws li kev tsim khoom.
COA
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Khoom npe |
CAS Nr |
Batch Number |
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Genistein hmoov |
446-72-0 |
MB2604151254 |
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Hnub tim tsim khoom |
Hnub Soj Ntsuam |
Hnub Kawg |
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2026/4/15 |
2026/4/16 |
2028/4/15 |
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Qauv Qty Puag |
Ntim |
Txoj Kev Xeem |
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200 KGS |
25KG / nruas |
HPLC |
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Yam khoom |
Txuj |
Cov txiaj ntsig |
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Lub cev khoom |
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Qhov tshwm sim |
Lub teeb daj hmoov |
Organoleptic |
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Xim |
Lub teeb daj |
Organoleptic |
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tsw |
Yam ntxwv |
Organoleptic |
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Kev soj ntsuam dav dav |
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Kev txheeb xyuas |
Zoo tib yam rau RS qauv |
HPLC |
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Astragaloside IV |
98% |
98.37% |
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Poob rau ziab |
Tsawg dua lossis sib npaug li 5.0% |
Eur.Ph.6.[2.8. 17] 4.02% |
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Tshauv |
Tsawg dua lossis sib npaug li 5.0% |
Eur.Ph.6.0[2.4. 16] 2.37% |
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Cov kab mob |
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Tshuaj tua kab Residue |
Raws li USP32<561> |
USP32<561>Ua raws |
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Lead (Pb) |
Tsawg dua lossis sib npaug li 3.0mg / kg |
Euro Ph6.0<2.2.58>ICP{0}}MS 2.1 |
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Arsenic (As) |
Tsawg dua lossis sib npaug li 2.0mg / kg |
Euro Ph6.0<2.2.58>ICP{0}}MS 1.9 |
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Cadmium (Cd) |
Tsawg dua lossis sib npaug li 1.0mg / kg |
Euro Ph6.0<2.2.58>ICP-MS 0.7 |
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Mercury (Hg) |
Tsawg dua lossis sib npaug li 0.1mg / kg |
Euro Ph6.0<2.2.58>ICP-MS 0.07 |
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Microbiological |
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Tag Nrho Phaj suav |
Tsawg dua lossis sib npaug li 1000cfu / g |
USP 30<61> 120 |
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Yeast & Pwm |
Tsawg dua lossis sib npaug li 100cfu / g |
USP 30<61> 40 |
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E. Coli. |
Tsis zoo |
USP 30<62>Ua raws |
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Salmonella |
Tsis zoo |
USP 30<62>Ua raws |
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Xaus |
Cov batch ua raws li IN-HOUSE tus qauv |
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Protein Tyrosine Kinase (PTK) Inhibition
Genistein yog ib qho ntawm feem ntau classic broad -spectrum kev sib tw inhibitors ntawm Protein Tyrosine Kinase (PTK) hauv kev tshawb fawb biochemical. PTKs ua lub luag haujlwm tseem ceeb hauv kev loj hlob ntawm tes, kev sib txawv, thiab kev xa cov teeb liab (xws li EGFR thiab VEGFR txoj hauv kev). Los ntawm kev khi rau ATP- khi qhov chaw ntawm PTKs, Genistein tiv thaiv cov protein phosphorylation thiab feem ntau siv los ua cov cuab yeej siv rau kev thaiv cov kev taw qhia hauv kev tshawb fawb molecular biology.
Estrogen Receptor (ER) Dual Regulation thiab Pob Txha Metabolism
Raws li phytoestrogen, Genistein nthuav qhia kev xaiv khi affinity rau estrogen receptors:
Receptor Selectivity: Nws txoj kev sib raug zoo rau ER yog qhov siab dua (txog kaum tawm zaus) dua li ER, ua rau nws siv cov ntaub so ntswg - xaiv cov kev cai tswj hwm.
Kev Tiv Thaiv Pob Txha: Los ntawm activating ER signaling nyob rau hauv osteoblasts, nws txhawb kev qhia ntawm osteoprotegerin (OPG) thiab inhibits receptor activator ntawm nuclear factor-κB ligand (RANKL), yog li suppressing osteoclast kev ua. Nws tau tshawb fawb dav dav rau kev txhim kho cov tshuaj thiab cov khoom noj ua haujlwm uas tsom mus rau kev mob osteoporosis postmenopausal.
Targeted Tumor Regulation thiab Cell Cycle Control
Cov kev tshawb fawb hauv vitro thiab hauv vivo qhia tias Genistein muaj ntau yam -lub hom phiaj los tiv thaiv- qog ua haujlwm:
Cell Cycle Arrest: Nws downregulates Cyclin B1 thiab CDK1, inducing G2/M theem cell voj voog ntes nyob rau hauv ntau yam qog nqaij hlav cancer (xws li mis, prostate, thiab cov qog nqaij hlav hauv plab).
Pro-apoptotic Pathways: Nws induces apoptosis los ntawm kev nce Bax / Bcl-2 piv thiab ua kom lub Caspase-3/9 cascade.
Inhibition ntawm Angiogenesis thiab Metastasis: Nws downregulates matrix metalloproteinases (MMP-2 / MMP-9) thiab vascular endothelial kev loj hlob yam (VEGF), thaiv angiogenesis thiab invasion nyob rau hauv lub qog microenvironment.
Oxidative Stress thiab Anti-Txoj Kev inflammatory (Nrf2 / NF-κB)
Genistein nthuav tawm dual antioxidant thiab tiv thaiv - cov txheej txheem inflammatory:
Dawb Radical Scavenging thiab Enzyme Induction: Tshaj tawm ncaj qha scavenging reactive oxygen hom (ROS), nws activates Nrf2/ARE txoj kev, upregulating endogenous antioxidant enzymes zoo li superoxide dismutase (SOD) thiab glutathione peroxidase (GSH{1}}Px).
Inflammatory Mediator Suppression: Nws inhibits classical NF-κB ua kom muaj zog, tom qab ntawd txo qis hauv inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), thiab pro-inflammatory cytokines xws li TNF- thiab IL-6.
Metabolic Regulation thiab Cardiovascular Protection
Hauv kev tshawb nrhiav kab mob metabolic, Genistein tau pom tias txhim kho insulin tsis kam thiab lipid profile:
Lipid Metabolism: Ua raws li lub ntuj agonist rau PPAR thiab PPAR, nws txhawb cov fatty acid oxidation thiab txo tag nrho cov cholesterol (TC), tsawg- ntom lipoprotein (LDL), thiab triglycerides.
Kev Tiv Thaiv Endothelial: Nws activates endothelial nitric oxide synthase (eNOS) kom nce nitric oxide (NO) tso tawm, txhim kho vascular endothelial tone thiab ua raws.
Cov dej num lom neeg thiab thaj chaw siv
- Pob txha Metabolism
Ntau qhov kev sim tshuaj ntsuam xyuas randomized (RCTs) qhia tau tias kev noj txhua hnub ntawm 40-54 mg genistein slows lumbar pob txha pob txha tsis txaus hauv cov poj niam postmenopausal. Cov txheej txheem hauv qab no suav nrog ER - kho kom haum xeeb ntawm kev ua haujlwm ntawm osteoblast thiab inhibition ntawm osteoclast sib txawv, txo cov pob txha resorption cim. Nws ua raws li cov khoom noj khoom haus raw khoom rau peri- cov pob txha mob menopausal, txawm hais tias cov pov thawj los ntawm loj - nplai ntev - lub sij hawm sim tseem tsub zuj zuj.
- Kev tiv thaiv kab mob plawv
Genistein txhim kho vascular endothelial muaj nuj nqi, txo LDL oxidation, inhibits vascular du nqaij proliferation thiab exerts anti-atherosclerotic inflammatory teebmeem. Cov kev tshawb fawb txog kab mob kis tau qhia tias cov pej xeem nrog ntev - lub sij hawm soy isoflavone tau txais tsawg dua kev pheej hmoo ntawm cov hlab plawv. Txawm li cas los xij, pov thawj rau cov txiaj ntsig ywj pheej los ntawm genistein ib leeg tseem txwv.
- Cosmetic Raw Khoom
Nws muab cov tshuaj tiv thaiv antioxidant thiab tiv thaiv -glycation teebmeem thiab inhibits tyrosinase kom txo tau UV-induced photoageing. Raws li SCCS kev ntsuam xyuas, qhov kev nyab xeeb ntawm cov genistein hauv cov tshuaj pleev ib ce yog 0.007%. Muaj peev xwm endocrine- cuam tshuam txog kev pheej hmoo yuav tsum raug txiav txim siab, thiab siab -kev sib xyaw ua ke yog txwv tsis pub. Nws yog siv rau hauv kev tiv thaiv - kev laus, kho daim tawv nqaij thiab ci ci cov qauv rau kev ua haujlwm hauv vitro.
- Tool Compound rau Cellular Experiments
Nws yog siv dav hauv kev tshawb fawb ntawm tes taw qhia raws li PTK inhibitor rau kev tshawb nrhiav tshuab.
FAQ
genistein siv rau dab tsi?
Genistein yog cov kua txiv hmab txiv ntoo uas siv los tswj cov tsos mob menopausal, txhawb cov pob txha ntom ntom, thiab txhawb kev mob plawv.
Dab tsi yog qhov chaw siab tshaj ntawm genistein?
Soybeans thiab fermented soy khoom yog cov khoom noj khoom haus zoo tshaj plaws ntawm genistein.
Cov kev mob tshwm sim ntawm genistein yog dab tsi?
Genistein, ib tsob nroj- muab tau los ntawm isoflavone feem ntau pom hauv cov taum pauv, tuaj yeem ua rau mob plab zom mov me me thiab cuam tshuam nrog cov tshuaj hormones- cov kab mob rhiab heev thaum noj ua cov tshuaj ntxiv.
Leej twg yuav tsum noj genistein?
Genistein yog ib tsob nroj - muab tau los ntawm isoflavone feem ntau txiav txim siab rau cov poj niam perimenopausal thiab postmenopausal cov poj niam nrhiav lwm txoj hauv kev los kho cov tshuaj hormone hloov pauv.
Yog tias koj tab tom nrhiav rau siab - zooGenistein hmoovcov chaw tsim khoom uas koj tuaj yeem tsim kom muaj sijhawm ntev -, kev sib koom tes ruaj khov, ces Shaanxi Medibridge Biotech Co., Ltd. yuav yog koj tus khub lag luam zoo tshaj plaws. Tsis txhob yig tiv tauj peb ntawmhi@medibridgeapi.com.
Cim npe nrov: genistein hmoov, Tuam Tshoj genistein hmoov manufacturers, lwm tus neeg, Hoobkas
