Andrographolide hmoovyog ib qho triterpenoid saponin pom feem ntau hauv Andrographis paniculata, tshuaj ntsuab me me. Andrographis paniculata, tseem hu ua "Indian Fennel," "Centella Asiatica," thiab lwm lub npe, loj hlob hauv cov chaw ntub dej xws li cov chaw ntub dej, cov ntug dej ntiav, cov teb, thiab lwm yam. Nws yog dav suav tias yog tshuaj muaj txiaj ntsig. Nws feem ntau suav nrog -andrographolide, -andrographolide, phenolic triterpenoid acids, esters, thiab lwm yam tshuaj. Lawv paub tias saponin tebchaw muaj cov qauv polycyclic. Triterpenoids muaj ntau yam kev ua ub no hauv cov nroj tsuag, suav nrog kev tiv thaiv - mob, antioxidant, thiab qhov txhab- kho cov teebmeem.
Nws tau ib txwm siv nyob rau hauv ntau hom tshuaj ntsuab thiab ntseeg tau tias muaj ntau yam kev pab kho mob. Cov kev tshawb fawb tau pom tias nws txhawb kev kho qhov txhab, tiv thaiv thiab kho daim tawv nqaij, tiv thaiv - mob thiab antioxidant, txhawb collagen synthesis, tshem tawm cov cua sov, detoxifies, yog anti- mob, thiab yog analgesic. Nws zoo kawg nkaus cuam tshuam rau cov kab mob thiab cov kab mob ua pa sab sauv thiab kab mob dysentery. Nws yog hu ua tshuaj tua kab mob ntuj. Tsis tas li ntawd, nws muaj peev xwm cuam tshuam rau kev paub txog kev ua haujlwm thiab lub siab lub ntsws kuj tau kawm. Nws, ib qho triterpenoid compound, tau nyiam ntau yam hauv tshuaj thiab kev saib xyuas neeg mob.
Shaanxi Medibridge Biotech Co., Ltd., Ltd. muab cov nroj tsuag rho tawm, cov khoom noj khoom haus, thiab cov khoom siv tshwj xeeb rau cov khoom sib txawv thiab kev xav tau. Peb txhawb nqa cov khoom ruaj khov, cov kev qhia tshwj xeeb niaj hnub sib xws, thiab cov kev pabcuam ntim hloov tau yooj yim rau cov khoom xyaw - raws li kev tsim khoom.
COA
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Khoom npe |
CAS Nr |
Batch Number |
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Andrographolide hmoov |
5508-58-7 |
MB2604151982 |
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Hnub tim tsim khoom |
Hnub Soj Ntsuam |
Hnub Kawg |
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2026/4/15 |
2026/4/16 |
2028/4/15 |
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Qauv Qty Puag |
Ntim |
Txoj Kev Xeem |
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100 KGS |
25KG / nruas |
HPLC |
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Yam khoom |
Txuj |
Cov txiaj ntsig |
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Kev tswj lub cev & tshuaj lom neeg |
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Qhov tshwm sim |
Dawb crystalline hmoov |
Ua raws |
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tsw & saj |
Yam ntxwv |
Ua raws |
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Assay |
98% |
98.15% |
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Particle loj |
100% dhau 80 mesh |
Ua raws |
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Kev txheeb xyuas |
Qhov zoo |
Ua raws |
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Poob rau ziab |
Tsawg dua lossis sib npaug li 5.0% |
Ua raws |
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Residue ntawm Ignition |
Tsawg dua lossis sib npaug li 5.0% |
Ua raws |
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Hnyav Hlau |
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Hnyav Hlau |
NMT 10 ppm |
Ua raws |
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Lead (Pb) |
NMT 3 ppm |
Ua raws |
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Arsenic (As) |
NMT 2 ppm |
Ua raws |
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Mercury (Hg) |
NMT 0.1 ppm |
Ua raws |
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Cadmium (Cd) |
NMT 1 ppm |
Ua raws |
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Microbiology Tswj |
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Tag Nrho Phaj suav |
NMT 3,000 cfu/g |
Ua raws |
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Total Poov & Pwm |
NMT300cfu/g |
Ua raws |
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E.coli |
Tsis zoo |
Ua raws |
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Salmonella |
Tsis zoo |
Ua raws |
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Staphylococcus |
Tsis zoo |
Ua raws |
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Xaus |
Cov batch ua raws li IN-HOUSE tus qauv |
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Biological Activities & Molecular Mechanisms
Kev Tiv Thaiv -Kev Ua Phem Txhaum Cai (Core Kev Tshawb Fawb Cov Lus Qhia)
Andrographolide ua raws li lub ntuj inhibitor ntawm NF -κB txoj kev.
1. Nws suppresses nuclear translocation ntawm NF-κB transcription factor thiab txo phosphorylation thiab degradation ntawm IκB .
2. Downregulates lub MAPK (p38, ERK, JNK) taw qhia txoj kev.
3. Ua kom txo tau qhov kev tso tawm ntawm pro-cov neeg kho mob inflammatory xws li TNF- , IL-6, IL-1 , iNOS thiab COX-2.
4. inhibits qhov ua kom NLRP3 inflammasome.
Cov qauv kev tshawb fawb ntsig txog suav nrog kev ua pa ua pa, mob plab hnyuv, o ntawm daim tawv nqaij, mob caj dab thiab mob ntsws mob.
Immunomodulatory kev ua
Nws exerts bidirectional immunomodulatory teebmeem: nws suppresses overactive inflammatory kab mob cov lus teb thaum pab txhawb kev tiv thaiv kab mob ntawm lub cev.
- Tswj kev ua kom cov macrophages, dendritic cells thiab T lymphocytes.
- Txo cov cua daj cua dub thiab txo lub cev tiv thaiv kab mob- cov ntaub so ntswg puas tsuaj hauv cov qauv kab mob.
Antimicrobial thiab Antiviral Activity
- Antibacterial: Nws qhia tau hais tias hauv vitro inhibitory cuam tshuam rau Staphylococcus aureus thiab qee cov tshuaj tiv thaiv kab mob, thiab inhibits kab mob biofilm tsim.
- Tshuaj tiv thaiv kab mob: Ntau qhov kev tshawb fawb hauv vitro qhia txog nws cov haujlwm inhibitory tiv thaiv cov kab mob hauv lub ntsws xws li kab mob khaub thuas thiab mob coronavirus. Cov txheej txheem npaj muaj xws li inhibition ntawm tus kab mob nkag, rov ua dua thiab raug mob tom qab. Hauv vivo pov thawj tseem txwv; nws tsis tuaj yeem siv ncaj qha los ua tshuaj tua kab mob.
- Antiparasitic: Qee qhov kev tshawb nrhiav hauv vitro qhia txog kev tiv thaiv -plasmodial kev ua haujlwm, uas tseem nyob rau theem pib tshawb fawb.
Cov ntawv thov muaj & Extended Domains
Pharmaceutical Industry (Classical Medicinal Siv):
Ua haujlwm tseem ceeb ntawm cov khoom siv tshuaj (API) rau Andrographolide Tablets thiab Dropping Pills, siv los kho mob tonsillitis, pharyngitis, bronchitis, thiab gastroenteritis.
Precursor rau Semi-Synthetic Derivatives: Vim nws cov dej tsis zoo solubility, nws yog dav siv los ua cov khoom pib los ua cov khoom sib txuas ntau dua, xws li Potassium Dehydroandrographolide Succinate (Chuanhuning) thiab Potassium Sodium Dehydroandrographolide Succinate rau kev txhaj tshuaj.
Tshuaj pleev ib ce & Dermatology:
Anti- Pob txuv & Sebum Control: Inhibits localized sebaceous qog o tshwm sim los ntawm Cutibacterium acnes thiab down- tswj 5$\\alpha$-reductase kev ua kom txo qis sebum secretion ntau dhau.
Soothing & Anti-Irritation: Ua raws li cov khoom siv kho cov tawv nqaij rhiab heev, sai sai tshem tawm erythema thiab stinging los ntawm tshuaj lom neeg los yog raug UV.
Green Feed & Antibiotic Alternatives in Animal Health:
Hauv cov ntsiab lus ntawm kev txwv tsis pub siv tshuaj tua kab mob thoob ntiaj teb hauv cov tsiaj pub tsiaj, Andrographolide Powder yog ib qho kev siv tshuaj tua kab mob uas muaj txiaj ntsig zoo uas ua rau lub plab ua haujlwm hauv cov tsiaj nyeg (xws li, nqaij qaib, piglets), tiv thaiv damp - cua kub raws plab, thiab txhawb kev tiv thaiv kab mob.
Lwm Cov Lus Qhia Txog Kev Tshawb Fawb
Hepatoprotection: Hauv cov qauv ntawm chemically induced daim siab raug mob thiab tsis yog - cawv fatty siab kab mob, nws mitigates hepatic oxidative kev nyuaj siab thiab inhibits hepatic o thiab fibrosis kev loj hlob.
Antioxidation: Scavenes ROS thiab qhib txoj hauv kev Nrf2 los txhim kho endogenous antioxidant systems suav nrog SOD thiab GSH.
Basic anti- tshawb fawb qog: Induces apoptosis thiab suppresses migration thiab ntxeem tau ntawm ntau cov qog cell kab nyob rau hauv vitro nrog xaiv los ntawm cov qog hlwb; qhov kev tshawb pom tseem txwv rau cov cellular thiab tsiaj qauv.
Cardioprotection: Nyob rau hauv cov qauv tsiaj, nws alleviates vascular o, tiv thaiv endothelial puas thiab txhim kho atherosclerotic ntsuas.
Kev Tshawb Fawb Yav Tom Ntej
- Kev tsim kho lub cev: phospholipid complexes, cyclodextrin suav nrog thiab nanoparticles los txhim kho cov dej solubility thiab qhov ncauj bioavailability.
- Kev hloov kho cov qauv: kev sib txuas ntawm andrographolide derivatives los txhim kho cov tshuaj pharmacokinetic thiab txhim kho lub hom phiaj affinity.
- Kev tsim cov tshuaj pleev ib ce ntawm daim tawv nqaij los daws cov teeb meem solubility thiab stability.
- Kev tshawb fawb ua ke: kev sib xyaw nrog lwm cov khoom xyaw ntuj tsim kom ua tiav kev sib koom ua ke los tiv thaiv- cov teebmeem inflammatory.
- Kev loj hlob ntawm kev ua liaj ua teb biostimulants thiab cog kev tiv thaiv kab mob.
FAQ
Dab tsi yog andrographolide siv rau?
Andrographolide yog lub ntsiab active compound pom nyob rau hauv cov tshuaj cog Andrographis paniculata, thiab nws yog siv feem ntau nyob rau hauv cov tshuaj ib txwm siv thiab noj tshuaj pab kom txo tau qhov mob thiab tua kab mob.
andrographolide yog dab tsi?
Andrographolide yog ib qho iab, nquag labdane diterpenoid compound muab rho tawm los ntawm cov nroj tsuag tshuaj Andrographis paniculata.
Puas yog andrographis nyuaj rau lub raum?
Yog lawm, andrographis tuaj yeem nyuaj rau ob lub raum, tshwj xeeb tshaj yog thaum noj cov koob tshuaj ntau lossis muab tso rau hauv cov hlab ntsha.
Puas yog andrographis zoo rau lub siab?
Andrographis qhia tau hais tias muaj txiaj ntsig hepatoprotective (siab-tiv thaiv) cuam tshuam) hauv kev tshawb fawb ib txwm thiab ua ntej, tab sis nws yuav tsum tau siv nrog ceev faj.
Yog tias koj tab tom nrhiav rau siab - zooAndrographolide hmoovcov chaw tsim khoom uas koj tuaj yeem tsim kom muaj sijhawm ntev -, kev sib koom tes ruaj khov, ces Shaanxi Medibridge Biotech Co., Ltd. yuav yog koj tus khub lag luam zoo tshaj plaws. Tsis txhob yig tiv tauj peb ntawmhi@medibridgeapi.com.
Cim npe nrov: andrographolide hmoov, Tuam Tshoj andrographolide hmoov manufacturers, lwm tus neeg, Hoobkas
