Extract hmoov Camptothecin(CPT) yog pyrroloquinoline cytotoxic alkaloid. Nws yog ib qho ntawm cov kev tshawb fawb ntxiv los tiv thaiv - cov tshuaj tiv thaiv kab mob ntawm tes nrog rau paclitaxel. Nws muaj nyob rau hauv cov txiv hmab txiv ntoo los yog cov hauv paus hniav ntawm Davidia cog Camptotheca acuminata. Lub hauv paus bark ntawm Camptotheca acuminata muaj cov teebmeem ntawm tshem tawm cov cua sov thiab detoxifying, dispersing knots, thiab txo o. Cov txiv hmab txiv ntoo muaj cov nyhuv activating ntshav ncig thiab tshem tawm cov ntshav stasis. Nws yog feem ntau siv los kho psoriasis, mob, thiab lwm yam tsos mob.
CPT muaj qhov tseem ceeb los tiv thaiv- cov kab mob tseem ceeb, kev solubility tsawg, thiab qib siab ntawm cov tshuaj tiv thaiv tsis zoo hauv kev sim ua ntej. Cov kws kho mob tshuaj muaj, dhau los, siv cov khoom no los tsim ntau yam CPTs hluavtaws thiab ntau yam khoom siv los ua kom lawv cov txiaj ntsig zoo. Tam sim no nws tsuas yog cov tshuaj uas ua rau topoisomerase I, uas tau nyiam dua tshiab rau CPT. Ntau yam CPT derivatives tau tsim thiab siv, xws li hydroxy CPT, topotecan, irinotecan, thiab lwm yam.
Shaanxi Medibridge Biotech Co., Ltd., Ltd. muab cov nroj tsuag rho tawm, cov khoom noj khoom haus, thiab cov khoom siv tshwj xeeb rau cov khoom sib txawv thiab kev xav tau. Peb txhawb nqa cov khoom ruaj khov, cov kev qhia tshwj xeeb niaj hnub sib xws, thiab cov kev pabcuam ntim hloov tau yooj yim rau cov khoom xyaw - raws li kev tsim khoom.
COA
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Khoom npe |
CAS Nr |
Batch Number |
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Extract hmoov Camptothecin |
7689-03-4 |
MB2604151254 |
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Hnub tim tsim khoom |
Hnub Soj Ntsuam |
Hnub Kawg |
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2026/4/15 |
2026/4/16 |
2028/4/15 |
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Qauv Qty Puag |
Ntim |
Txoj Kev Xeem |
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100 KGS |
25KG / nruas |
HPLC |
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Yam khoom |
Txuj |
Cov txiaj ntsig |
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Qhov tshwm sim |
Lub teeb daj crystalline hmoov |
Ua raws |
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Melting point |
Txog 205 degree |
206.4℃~ 206.7 degree |
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Kev txheeb xyuas |
Ua tau raws li qhov yuav tsum tau ua |
Ua raws |
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Qhov tshwm sim ntawm kev daws teeb meem |
Ntshiab, tsis khaus ntau dua Y7 |
Ua raws |
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PH |
2.4~3.0 |
2.60 |
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Poob rau ziab |
Tsawg dua los yog sib npaug li 0.5% |
0.04% |
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Sulfated tshauv |
Tsawg dua lossis sib npaug li 0.1% |
0.01% |
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Total Heavy metals |
Tsawg dua lossis sib npaug li 10 ppm |
<10 ppm |
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Arsenic |
Tsawg dua lossis sib npaug li 3 ppm |
Ua raws |
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Coj |
Tsawg dua lossis sib npaug li 3 ppm |
Ua raws |
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Cov khoom muaj feem xyuam |
Tsawg dua lossis sib npaug li 0.25% |
Ua raws |
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Assay |
99.0%~101.0% |
99.8% |
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Tag Nrho Phaj suav |
Tsawg dua lossis sib npaug li 1000cfu / g |
Ua raws |
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Yeast & Pwm |
Tsawg dua lossis sib npaug li 100cfu / g |
Ua raws |
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E. Coil |
Tsis zoo |
Tsis zoo |
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Salmonella |
Tsis zoo |
Tsis zoo |
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Xaus |
Cov batch ua raws li IN-HOUSE tus qauv |
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Pharmacology & Mechanism of Action
Lub hom phiaj tshwj xeeb ntawm Topoisomerase I (Topo I)
Mechanism: Camptothecin yog thawj lub npe hu ua topoisomerase I (Topo I) inhibitor. Thaum lub sij hawm DNA replication thiab transcription, Topo I yog lub luag hauj lwm rau cleaving thiab rejoining ib leeg -stranded DNA los txo supercoiling nro. Camptothecin tshwj xeeb khi rau "Topo I-DNA complex", ua kom ruaj khov covalent ternary complex uas tiv thaiv cov re-ligation ntawm DNA strands.
Cytotoxic Mechanism: Raws li replication lossis transcription machinery collides nrog no ternary complex, nws ua rau irreversible DNA ob -strand so (DSBs), activating apoptotic signaling pathways (xws li p53) thiab inducing programmed cell tuag nyob rau hauv S-phase qog hlwb.
Core Pharmacophore thiab pH-Txoj kev sib npaug
Lub camptothecin molecule muaj ib qho tseem ceeb E-ring lactone qauv.
pH-Txoj kev hloov pauv hloov pauv: Raws li lub cev muaj zog (pH 7.4), qhib - nplhaib carboxylate daim ntawv thiab kaw- nplhaib lactone daim ntawv muaj nyob hauv qhov sib npaug sib npaug. Tsuas yog kaw -ring lactone daim ntawv muaj kev tiv thaiv- qog nqaij hlav. Daim ntawv qhib - nplhaib carboxylate tsis muaj kev tiv thaiv- qog ua haujlwm thiab khi nrog kev sib raug zoo rau tib neeg cov ntshav albumin (HSA), ua rau muaj kev phom sij loj xws li hemorrhagic cystitis thiab myelosuppression.
Phytochemistry & Extraction txheej txheem
Botanical Sources & Extraction
Cov peev txheej: Feem ntau muab rho tawm los ntawm cov txiv hmab txiv ntoo (Fructus Camptothecae), cov cag ntoo, lossis tsob ntoo tawv ntoo ntawm Camptotheca acuminata.
Cov txheej txheem rho tawm: Cov txheej txheem kev siv cov kuab tshuaj organic (xws li chloroform, ethanol, lossis methanol) rau leaching, ua raws li kev rho tawm, decolorization, recrystallization, lossis kab chromatography rau purification.
Synthetic Biology & Green Production (Cov lus qhia yav tom ntej)
Txhawm rau kov yeej cov kev txwv ntawm cov khoom siv cog qoob loo, cov kws kho biologists yog elucidating monoterpene indole alkaloid (MIA) biosynthetic txoj hauv kev ntawm camptothecin los tsim heterologous biosynthetic platforms (cell factories) nyob rau hauv cov tswv xws li poov xab los yog luam yeeb, ua kom ruaj khov thiab eco{0} cov ntaub ntawv raw khoom.
Tshuaj Kho Mob Chemistry & Cov Qauv Hloov Kho
Vim muaj qhov tsis zoo ntawm lub cev camptothecin- xws li cov dej tsis zoo soluble (sparingly soluble hmoov), tsis muaj ntshav plasma stability (tsis ruaj tsis khov lactone nplhaib), thiab siab toxicity- kev hloov kho raws li camptothecin core (CPT) tau dhau los ua ib phau ntawv piv txwv ntawm tshuaj.
- Semi-Synthetic Dej-Soluble Derivatives:
Topotecan: Ib qho dej- soluble side chain (-CH_2-N(CH_3)_2) yog qhia ntawm C-9 txoj hauj lwm, thiab ib pawg -OH ntawm txoj hauj lwm C-10, txhim kho cov dej solubility thiab bioavailability; nws yog siv nyob rau hauv kev kho mob rau me me cell ntsws cancer thiab zes qe menyuam cancer.
Irinotecan (CPT-11): Hloov kho ntawm C-10 nrog cov dej-soluble dipiperidino sab saw, ua raws li cov tshuaj uas tso tawm cov metabolite SN-38 hauv vivo ntawm carboxylesterase cleavage; nws ua hauj lwm pab raws li ib tug thawj-kab kev kho mob rau mob qog noj ntshav.
- Structural Modification Strategies:
A/B Nplhaib Hloov Kho: Hloov pauv nrog electron- rho tawm lossis electron- pub dawb pab pawg ntawm C-9, C-10, lossis C-11 tuaj yeem hloov pauv kev sib raug zoo rau Topo I thiab txhim kho lactone nplhaib stability.
E-Kev Tiv Thaiv Lub Nplhaib: Tiv thaiv lub nplhaib lactone qhib thiab tsis ua haujlwm hauv cov ntshav los ntawm kev tsim cov tshuaj (xws li, esterification) lossis kev tiv thaiv ntawm 20-txoj haujlwm hydroxyl pawg.
Formulation & Novel Drug Delivery Systems (DDS)
Extracted natural camptothecin nyoos hmoov zoo li daj ntseg daj mus rau lub teeb daj crystalline hmoov, ua ib qho zoo tagnrho cov khoom xyaw rau kev tsim tshiab nanocarriers.
- Nanocarrier Encapsulation & Kev Tiv Thaiv Lub Cev
Liposomes & Polymeric Micelles: Encapsulating heev hydrophobic camptothecin nyob rau hauv lub hydrophobic core ntawm nanocarriers cais nws los ntawm plasma ib puag ncig, tiv thaiv lub nplhaib lactone los ntawm alkaline hydrolysis / nplhaib qhib thiab txuas nws ncig ib nrab- lub neej hauv vivo.
- Targeted & Precision xa tuaj
Antibody-Drug Conjugates (ADCs): Xws li Sacituzumab Govitecan (SG) tsom rau TROP-2, qhov twg cov tshuaj lom neeg lub cev yog camptothecin derivative SN-38.
Nanoprodrugs & Tus kheej- Cov khoom sib dhos: Polymer chemistry yog siv los sib txuas cov camptothecin mus rau cov pob txha hydrophilic los ntawm kev txhawb nqa - cov ntawv cog lus teb (xws li disulfide lossis acid- cov ntawv cog lus rhiab), ua tiav cov tshuaj tiv thaiv microenviment hauv cov qog.
FAQ
Camptothecin siv rau dab tsi?
Camptothecin yog ib tsob nroj - muab cov nroj tsuag uas siv los ua cov tshuaj topoisomerase I inhibitor rau lub hom phiaj thiab kho ntau yam qog noj ntshav.
Puas yog camptothecin yog ib yam khoom ntuj tsim?
Yog lawm, camptothecin yog ib yam khoom ntuj tsim.
Puas yog camptothecin tseem siv niaj hnub no?
Txawm hais tias cov khoom qub camptothecin tsis tshua siv ncaj qha niaj hnub no vim yog cov dej tsis zoo solubility thiab cov kev mob tshwm sim hnyav, nws cov derivatives semisynthetic thiab analogs tau dav thiab siv tau zoo hauv kev kho mob qog noj ntshav niaj hnub no.
Cov kev phiv ntawm camptothecin yog dab tsi?
Camptothecin thiab nws cov derivatives niaj hnub (xws li irinotecan thiab topotecan) feem ntau ua rau muaj kev phiv xws li mob raws plab, mob pob txha, xeev siab, ntuav, thiab plaub hau poob.
Yog tias koj tab tom nrhiav rau siab - zooExtract hmoov Camptothecincov chaw tsim khoom uas koj tuaj yeem tsim kom muaj sijhawm ntev -, kev sib koom tes ruaj khov, ces Shaanxi Medibridge Biotech Co., Ltd. yuav yog koj tus khub lag luam zoo tshaj plaws. Tsis txhob yig tiv tauj peb ntawmhi@medibridgeapi.com.
Cim npe nrov: Tuam Tshoj extract hmoov camptothecin manufacturers, lwm tus neeg, Hoobkas
