Colchicine hmoovyog ib qho alkaloid rho tawm los ntawm corms thiab noob ntawm * Colchicum autumnale * (ib tug tswv cuab ntawm tsev neeg Liliaceae); Nws kuj tshwm sim nyob rau hauv * Gloiosa superba * thiab * Iphigenia indica * (yav tas los * Colchicum luteum *), nrog rau cov concentrations ntawm 0.11% thiab 0.1%, feem. Nws zoo nkaus li daj ntseg koob -zoo li cov muaju, muaj ntxhiab tsw me ntsis, thiab saj iab. Nws muaj qhov melting point ntawm 157℃thiab yooj yim soluble hauv dej txias, cawv, chloroform, thiab formaldehyde; Txawm li cas los xij, nws muaj qhov tsis zoo solubility hauv dej kub, yog me ntsis soluble hauv benzene thiab diethyl ether, thiab zoo li insoluble hauv roj av ether. Cov tshuaj 0.5% muaj pH ntawm 5.9, thiab nws toxicity tuaj yeem txo los ntawm hydrolysis nrog ammonia. Colchicine nthuav tawm los tiv thaiv-cov khoom qog thiab inhibits cellular mitosis. Tus kws tshawb fawb Italian Pernice thawj zaug pom cov teebmeem ntawm colchicine ntawm mitosis hauv 1889; Nws tau piav qhia txog yuav ua li cas cov tshuaj raug ntes hauv cov theem metaphase ntawm kev faib tawm hauv cov kab mob hauv plab hnyuv ntawm cov dev, cuam tshuam cov cuab yeej spindle, ua rau tuag tes tuag taw chromosomal txav, thiab ua rau muaj coob tus hlwb nyob twj ywm nyob rau hauv ib qho txawv txav mitotic metaphase xeev. Hom kev faib txawv txawv no tshwm sim los ntawm colchicine hu ua "C-mitosis" (colchicine mitosis). Colchicine yog cov tshuaj siv dav tshaj plaws hauv kev tshuaj xyuas karyotype thiab induction ntawm polyploidy. Kev ua tau zoo ntawm cov tshuaj muaj txiaj ntsig zoo nrog rau qhov concentration ntawm nws cov kua dej aqueous; qhov siab dua qhov concentration, cov nyhuv muaj zog dua. Ntau hom nroj tsuag thiab cov ntaub so ntswg muaj ntau cov lus teb rau colchicine.
Shaanxi Medibridge Biotech Co., Ltd., Ltd. muab cov nroj tsuag rho tawm, cov khoom noj khoom haus, thiab cov khoom siv tshwj xeeb rau cov khoom sib txawv thiab kev xav tau. Peb txhawb nqa cov khoom ruaj khov, cov kev qhia tshwj xeeb niaj hnub sib xws, thiab cov kev pabcuam ntim hloov tau yooj yim rau cov khoom xyaw - raws li kev tsim khoom.
COA
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Khoom npe |
CAS Nr |
Batch Number |
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Colchicine hmoov |
64-86-8 |
MB2604052352 |
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Hnub tim tsim khoom |
Hnub Soj Ntsuam |
Hnub Kawg |
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2026/4/05 |
2026/4/06 |
2028/4/05 |
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Qauv Qty Puag |
Ntim |
Txoj Kev Xeem |
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100 KGS |
25KG / nruas |
HPLC |
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Yam khoom |
Txuj |
Cov txiaj ntsig |
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Qhov tshwm sim |
Lub teeb daj hmoov |
Ua raws |
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Assay |
Ntau dua lossis sib npaug li 98% |
98.23% |
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Mesh loj |
100% dhau 80 mesh |
Ua raws |
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Tshauv |
Tsawg dua lossis sib npaug li 5.0% |
2.85% |
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Poob rau ziab |
Tsawg dua lossis sib npaug li 5.0% |
2.82% |
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Hnyav hlau |
Tsawg dua lossis sib npaug li 10ppm |
Ua raws |
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Pb |
Tsawg dua lossis sib npaug li 2ppm |
Ua raws |
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Raws li |
Tsawg dua lossis sib npaug li 1ppm |
Ua raws |
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Hg |
Tsawg dua lossis sib npaug li 0.1ppm |
Ua raws |
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Cov tshuaj tua kab residue |
Tsis zoo |
Tsis zoo |
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Tag nrho cov phaj suav |
Tsawg dua lossis sib npaug li 1000cfu / g |
Ua raws |
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Yeast & Pwm |
Tsawg dua lossis sib npaug li 100cfu / g |
Ua raws |
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E.coli |
Tsis zoo |
Tsis zoo |
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Salmonella |
Tsis zoo |
Tsis zoo |
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Xaus |
Cov batch ua raws li IN-HOUSE tus qauv |
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Kev Ua Si lom zem & Molecular Mechanisms
Anti-mitotic / Cytoskeleton Targeting (cov ntsiab lus tseem ceeb)
Colchicine khi reversibly rau tubulin dimers, blocks tubulin polymerization rau hauv microtubules.
1. Ncua microtubule sib dhos, cuam tshuam kev tsim spindle thaum lub sij hawm cell mitosis.
2. ntes cell voj voog ntawm metaphase.
>Qhov no yog lub hauv paus rau ob qho tib si nws tiv thaiv -proliferative effect thiab cellular toxicity.
Kev Tiv Thaiv -Kev Ua Phem Txhaum Cai (kev siv tshuaj kho mob tseem ceeb)
1. Inhibits microtubule- nyob ntawm leukocyte tsiv teb tsaws thiab neutrophil chemotaxis rau qhov chaw mob.
2. Txo neutrophil adhesion thiab degranulation, suppresses tso tawm pro-inflammatory mediators.
3. inhibits NLRP3 inflammasome los ua ke thiab ua kom, txo qis IL-1 secretion.
4. Modulates inflammasome, NF-κB thiab MAPK signaling cascades.
Kev Tiv Thaiv -fibrotic Kev Ua Haujlwm (qhov chaw tshawb fawb nquag)
Hauv cov qauv preclinical: inhibits fibroblast proliferation, collagen deposition, myofibroblast transformation ntawm TGF- pathway modulation. Kawm hauv lub ntsws, lub raum, kab mob siab fibrosis.
Cardiovascular & Vascular Research
Tsawg -kev tshawb fawb koob tshuaj colchicine tsom rau atherosclerotic o: txo vascular macrophage infiltration, stabilizes atherosclerotic plaques. Kev sim tshuaj ntsuam xyuas nws siv rau kev tiv thaiv theem nrab tom qab myocardial infarction thiab pericarditis.
Anti-cov qog nqaij hlav Basic Research
Vim yog tubulin inhibition, colchicine tau tshawb xyuas ntxov ua tus tiv thaiv -tus neeg mob qog noj ntshav. Txawm li cas los xij, ** lub cev muaj kuab lom siab txwv tsis pub siv tshuaj khomob raws li kev khomob **. Ntau qhov kev tshawb fawb tau tsom mus rau colchicine prodrugs, tsom conjugates thiab liposomal xa mus los txo cov kab mob toxicity.
Daim ntawv thov teb
Pharmacological Research & Analytical Chemistry
- Cov cuab yeej cuab tam classic rau cytoskeleton, tubulin thiab cell voj voog tshawb fawb hauv cell biology.
- Cov qauv siv rau HPLC kom muaj nuj nqis ntawm cov ntsiab lus colchicine hauv cov nroj tsuag tshuaj thiab cov extracts.
- Kev tswj kom zoo rau kev tshawb fawb mob ntsws thiab mob neutrophil.
Pharmaceutical Industry (cov ntawv thov tseem ceeb)
Pom zoo soj ntsuam indications:
1. Kev kho mob gout nres thiab gout flare prophylaxis.
2. Cov kab mob pericarditis.
Hom ntawv: ntsiav tshuaj qhov ncauj. Yuav tsum tau noj tshuaj nruj me ntsis. Colchicine API yog tswj cov khoom siv raw hauv ntau lub tebchaws vim muaj kev pheej hmoo toxicity.
Biomedical Material & Drug Delivery Research
Prodrug tsim, liposome, nanoparticle thiab antibody -kev tshawb fawb tshuaj conjugate (ADC), kom ua tiav lub hom phiaj xa khoom thiab txo cov kab mob lom.
Kev tshawb fawb los tiv thaiv-fibrosis / mob plawv
Preclinical thiab soj ntsuam kev sim rau plaque stabilization, tom qab- mob plawv mob, kab mob fibrotic, tseem nyob rau hauv kev soj ntsuam tsis tu ncua.
Kev Tshawb Fawb Txog Tam Sim No & Cov Kev Tshawb Fawb Yav Tom Ntej
- Lub hom phiaj xa khoom: liposomes, nanoparticles, prodrugs kom txo cov kab mob toxicity thaum khaws cov bioactivity hauv zos.
- Kev hloov kho cov qauv: semi-synthetic colchicine analogues los txhim kho tubulin khi xaiv xaiv thiab nthuav kho qhov ntsuas ntsuas.
- Kev tshuaj xyuas qhov tseeb tshiab: ntev- kev soj ntsuam kev nyab xeeb rau cov hlab plawv thiab cov kab mob fibrotic.
- Synthetic biology biosynthesis: engineered microbial los yog cog cell factories rau sustainable colchicine ntau lawm, txo kev cia siab rau kev cog qoob loo.
- Kev tshawb nrhiav kev sib xyaw ua ke: qis- koob tshuaj colchicine ua ke nrog lwm cov tshuaj tiv thaiv - cov tshuaj tiv thaiv rau kev sib koom ua ke, txo tus neeg noj ntau npaum li cas.
FAQ
colchicine siv rau dab tsi?
Colchicine yog ib hom tshuaj uas siv los kho thiab tiv thaiv kab mob gout flares thiab tswj tsev neeg Mediterranean fever (FMF).
Puas tuaj yeem colchicine crushed?
Qee cov qauv Colchicine Oral Tablet formulations tuaj yeem muab faib los yog crushed, tab sis koj yuav tsum nco ntsoov nrog koj tus kws muag tshuaj lossis kws kho mob ua ntej hloov cov tshuaj.
Dab tsi yog daim ntawv ntawm colchicine?
Ntuj colchicine yog cov nroj tsuag muaj zog uas tau muab rho tawm los ntawm lub caij nplooj zeeg crocus (Colchicum autumnale) thiab lub yeeb koob lily (Gloriosa superba).
Dab tsi yog qhov tshwm sim loj tshaj ntawm colchicine?
Qhov loj tshaj thiab feem ntau tshwm sim ntawm colchicine yog mob plab hnyuv loj, tshwj xeeb yog raws plab, nrog rau xeev siab, ntuav, thiab mob plab.
Yog tias koj tab tom nrhiav rau siab - zooColchicine hmoovcov chaw tsim khoom uas koj tuaj yeem tsim kom muaj sijhawm ntev -, kev sib koom tes ruaj khov, ces Shaanxi Medibridge Biotech Co., Ltd. yuav yog koj tus khub lag luam zoo tshaj plaws. Tsis txhob yig tiv tauj peb ntawmhi@medibridgeapi.com.
Cim npe nrov: Tuam Tshoj colchicine hmoov manufacturers, lwm tus neeg, Hoobkas
