Chrysophanol hmoov, tseem hu ua chrysophanic acid, yog muab rho tawm los ntawm cov hauv paus hniav thiab rhizomes ntawm Polygonaceae cog Rheum palmata. Nws yog ib tug natural compound dav siv nyob rau hauv tshuaj ntsuab tshuaj ntsuab thiab yog ib feem ntawm flavonoids. Hauv tshuaj ntsuab tshuaj ntsuab, nws yog dav siv los kho cov kab mob hauv plab xws li cem quav. Nws cov nyhuv laxative tuaj yeem ua rau mob plab hnyuv peristalsis thiab txhawb kev tso tawm, yog li nws feem ntau siv los kho cem quav. Tsis tas li ntawd, chrysophanic acid kuj ntseeg tau tias muaj cov tshuaj tiv thaiv - mob thiab cov kab mob tua kab mob thiab muaj cov ntawv thov tshwj xeeb hauv kev kho qee qhov mob - ntsig txog kab mob.
Raws li ib qho kev tivthaiv rho tawm los ntawm cov nroj tsuag rhubarb, chrysophanic acid feem ntau muaj cov teebmeem ntawm inhibiting kab mob kev loj hlob, stimulating paj excitement, thiab antioxidant teebmeem. Nws yog siv los kho cov kab mob thiab tiv thaiv kev laus. Nws muaj cov txiaj ntsig ntawm inhibiting kab mob kev loj hlob tawm tsam ntau yam kab mob, xws li Streptococcus pneumoniae, Bacillus influenzae, Coccus catarrhalis, thiab lwm yam. Tsis tas li ntawd, chrysophanic acid tuaj yeem ua rau cov hlab ntsha stimulation, accelerate cov metabolism ntawm cov kab mob sib txawv, thiab cuam tshuam cov tshuaj tiv thaiv oxidative simult dawb radicals. Chrysophanic acid feem ntau yog siv los kho cov kab mob cuam tshuam los ntawm cov kab mob kab mob thiab muaj suab nrov.
Shaanxi Medibridge Biotech Co., Ltd., Ltd. muab cov nroj tsuag rho tawm, cov khoom noj khoom haus, thiab cov khoom siv tshwj xeeb rau cov khoom sib txawv thiab kev xav tau. Peb txhawb nqa cov khoom ruaj khov, cov kev qhia tshwj xeeb niaj hnub sib xws, thiab cov kev pabcuam ntim hloov tau yooj yim rau cov khoom xyaw - raws li kev tsim khoom.
COA
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Khoom npe |
CAS Nr |
Batch Number |
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Chrysophanol hmoov |
481-74-3 |
MB2604151254 |
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Hnub tim tsim khoom |
Hnub Soj Ntsuam |
Hnub Kawg |
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2026/4/15 |
2026/4/16 |
2028/4/15 |
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Qauv Qty Puag |
Ntim |
Txoj Kev Xeem |
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100 KGS |
25KG / nruas |
HPLC |
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Yam khoom |
Txuj |
Cov txiaj ntsig |
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Assay |
Ntau dua lossis sib npaug rau 98% Chrysophanol / Chrysophanic Acid |
99.36% |
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Siv Part |
Rheum palmatum L cag |
Ua raws |
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Qhov tshwm sim |
Cov hmoov daj |
Cov hmoov daj |
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tsw & saj |
Yam ntxwv |
Yam ntxwv |
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Txoj Kev Xeem |
HPLC |
HPLC |
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Cov yam ntxwv ntawm lub cev |
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Sieve Analysis |
NLT 100% dhau 80 mesh |
80 mesh |
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Poob rau ziab |
Tsawg dua lossis sib npaug li 4.0% |
Tsawg dua lossis sib npaug li 4.0% |
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Tshauv Ntsiab Lus |
Tsawg dua lossis sib npaug li 2.0% |
Tsawg dua lossis sib npaug li 2.0% |
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Residual Solvents |
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Ethanol |
Tsawg dua lossis sib npaug li 5000ppm |
Ua raws |
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Total Heavy Metals |
Tsawg dua lossis sib npaug li 20ppm |
0.26% |
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Kev ntsuam xyuas Microbiological |
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Tag Nrho Phaj suav |
1000cfu/g |
Ua raws |
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Total Poov & Pwm |
100 cfu/g |
Ua raws |
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E. Coli |
Tsis zoo |
Tsis zoo |
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Salmonella |
Tsis zoo |
Tsis zoo |
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Staphylococcus |
Tsis zoo |
Tsis zoo |
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Xaus |
Cov batch ua raws li IN-HOUSE tus qauv |
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Natural Sources thiab Phytochemical yam ntxwv
Chrysophanol tau tshaj tawm nyob rau hauv ntau cov nroj tsuag thiab tej yam fungi. Cov chaw lom neeg muaj xws li:
- Rheum hom, xws li Rheum palmatum thiab Rheum officinale
- Rumex hom
- Polygonum hom
- Cassia los yog Senna
- Qee hom aloe
- Xaiv lichens, fungi, thiab microorganisms
Sigma-Aldrich sau tseg tias chrysophanol tshwm sim nyob rau hauv cov tshuaj rhubarb thiab tej zaum yuav ua hauj lwm los yog analytical cov ntsiab lus ntawm ntau yam anthraquinone- muaj cov tshuaj crude. Sigma-Aldrich
Free thiab Conjugated Forms
Hauv cov ntaub ntawv botanical, chrysophanol tuaj yeem tshwm sim hauv ob daim ntawv tseem ceeb:
Dawb anthraquinone daim ntawv: chrysophanol yog tam sim no raws li unconjugated aglycone.
Conjugated daim ntawv: chrysophanol yog txuas rau ib los yog ntau dua qab zib residues los ntawm glycosidic bonds, tsim anthraquinone glycosides.
Yog li ntawd, kev soj ntsuam cov txiaj ntsig rau "dawb chrysophanol" thiab "tag nrho chrysophanol" yuav txawv heev. Acid hydrolysis lossis enzymatic hydrolysis tuaj yeem tso cov aglycone los ntawm cov ntaub ntawv sib txuas, feem ntau ua rau muaj qhov ntsuas siab dua chrysophanol concentration.
Tau qhov twg los-Variability nyob ntawm
Cov ntsiab lus chrysophanol ntawm botanical cov ntaub ntawv yuav cuam tshuam los ntawm:
- Hom thiab botanical authentication
- Cog ib feem siv
- Cog hnub nyoog thiab kev loj hlob theem
- Geographical keeb kwm thiab kev nyab xeeb
- Lub caij sau qoob
- Txheej txheem los yog ib txwm npaj txoj kev
- Qhuav kub
- Cia cov av noo thiab lub teeb raug
- Fungal contamination thiab tshuaj degradation
Pharmacological Activities thiab Proposed Mechanisms
Chrysophanol tau raug tshawb fawb txog kev mob o, oxidative kev nyuaj siab, qog- cell biology, metabolism, neuroprotection, cardiovascular muaj nuj nqi, thiab antimicrobial kev ua. Txawm li cas los xij, feem ntau muaj pov thawj los ntawm kev sim hauv vitro thiab cov qauv tsiaj thiab yuav tsum tsis txhob raug txhais raws li kev pom zoo ntawm kev siv tshuaj kho mob hauv tib neeg.
- Anti- Kev Tshawb Fawb Txog Kab Mob
Tshaj tawm cov kev taw qhia txoj hauv kev thiab molecular mediators suav nrog:
- NF-κB
- MAPKs, suav nrog p38, JNK, thiab ERK
- NLRP3/caspase-1 inflammasome signaling
- COX-2 and iNOS
- TNF- , IL-1 , and IL-6
- PPAR thiab lwm yam metabolic- cov tshuaj tiv thaiv kab mob
Pom pom cov teebmeem hauv cov tshuab sim yuav suav nrog txo qis kev tsim cov pro-cov neeg kho mob inflammatory, kev tawm tsam ntawm cov teeb liab inflammatory, lossis kev hloov kho ntawm lub cev tiv thaiv kab mob- kev ua haujlwm ntawm tes.
Oxidative Stress thiab Cov ntsiab lus -Txoj kev cuam tshuam dual
Cov kev ua redox ntawm chrysophanol zoo li yog cov ntsiab lus tseem ceeb heev - nyob ntawm.
Hauv qee cov qauv kev sim tiv thaiv, nws tuaj yeem txhim kho cov kab mob antioxidant xws li superoxide dismutase, catalase, glutathione, lossis Nrf2 / HO-1 signaling.
Hauv qee cov qog nqaij hlav-cov qauv ntawm tes, nws tuaj yeem txhawb kev tsim cov pa oxygen reactive, mitochondrial tsis ua haujlwm, thiab ATP depletion.
Tumor-Kev tshawb fawb ntawm tes
Chrysophanol tau raug tshawb xyuas hauv ntau lub cellular qauv rau nws lub peev xwm muaj peev xwm:
- Inhibit cell proliferation
- Modulate cell -cycle progression
- Induce mitochondrial apoptosis
- Hloov cov pa oxygen reactive thiab cellular ATP qib
- Tswj EGFR/AKT/mTOR thiab lwm yam kev taw qhia
- Kev cuam tshuam kev tsiv teb tsaws, ntxeem tau, lossis cov cim hloov pauv ntawm epithelial-mesenchymal
- Ua rau necrosis lossis ferroptosis- cuam tshuam cov kev hloov pauv hauv hom cell xaiv
Cov kev soj ntsuam no sawv cev rau cov tshuaj preclinical - tshawb pom cov pov thawj tau muab los ntawm cov qauv ntawm tes thiab tsiaj. Chrysophanol tsis yog ib qho tshuaj tiv thaiv kab mob uas tau pom zoo, thiab cov txiaj ntsig zoo hauv vitro tsis tuaj yeem hloov pauv ncaj qha rau hauv tib neeg koob tshuaj.
Antimicrobial thiab Antifungal tshawb fawb
Chrysophanol thiab lwm yam anthraquinones tau qhia txog kev ua haujlwm inhibitory tiv thaiv cov kab mob thiab cov kab mob hauv vitro. Cov kev tshawb fawb yav dhau los tau soj ntsuam cov tshuaj tiv thaiv kab mob ntawm anthraquinone derivatives cais los ntawm Rheum hom, thiab SCBT kuj txheeb xyuas chrysophanol ua ib qho chaw siv hauv kev tshawb fawb tshuaj tua kab mob.
Neurological, Cardiovascular, thiab Organ -Kev Tiv Thaiv Kev Tshawb Fawb
Cellular thiab tsiaj kev tshawb fawb tau tshuaj xyuas chrysophanol hauv cov qauv kev sim nrog:
- Cerebral ischemia - kev raug mob rov qab
- Neuroinflammation thiab oxidative puas
- Myocardial raug mob
- Lub raum los yog pulmonary o
- Hepatic stellate-kev ua haujlwm ntawm tes thiab fibrosis
- Cov pob txha metabolism thiab osteoblast sib txawv
Cia thiab ruaj khov
Cov qauv ntsuas ntsuas feem ntau khaws cia ntawm 2-8 degree. Sigma-Aldrich qhia qhov ntsuas kub ntawm 2-8℃rau nws cov qauv tshuaj ntsuam chrysophanol thiab sau tseg tias cov khoom muaj lub neej txee tsawg.
Cov lus pom zoo khaws cia dav dav suav nrog:
- Khaws rau hauv lub thawv kaw nruj nreem
- Tiv thaiv los ntawm lub teeb
- Khaws tej yam kev mob qhuav
- Tsis txhob sib cuag nrog cov oxidizing muaj zog
- Txo qhov rov qhib lub thawv
- Xav txog inert-gas tiv thaiv rau ntev- lub sij hawm cia
- Khaws cov kev daws teeb meem hauv aliquots kom txo qis dua khov-thaw mus
- Muab cov kev daws teeb meem ua haujlwm luv luv luv dua li cov khoom siv
Kev ruaj ntseg ntawm cov khoom siv tsis pom zoo sib npaug hauv DMSO, methanol, aqueous buffer, lossis cell- kab lis kev cai nruab nrab.
FAQ
Acidum Chrysophanicum cream siv rau dab tsi?
Acidum chrysophanicum cream los yog ointment yog ib qho tshuaj homeopathic tshuaj uas siv los tswj cov tawv nqaij mob uas tshwm sim los ntawm scaling, tuab crusts, thiab khaus khaus.
Koj puas tuaj yeem siv cov kua qaub chryso rau ntawm koj lub ntsej muag?
Yog lawm, koj tuaj yeem siv Acid Chryso Ointment rau ntawm koj lub ntsej muag yog tias koj kho cov mob tshwj xeeb xws li tawv taub hau tawg uas txuas mus rau lub ntsej muag, psoriasis, lossis qhuav eczema.
Dab tsi yog chrysophanicum acidum siv rau?
Acidum Chrysophanicum (Chrysophanic acid) yog ib qho tshuaj homeopathic muab tau los ntawm rhubarb, lichens, thiab Goa hmoov, feem ntau yog siv los tswj cov tawv nqaij ntev thiab mob qhov muag.
Acid chryso cream ua haujlwm li cas?
Acid Chryso cream ua haujlwm los ntawm cov khoom xyaw nquag Acidum chrysophanicum (tseem hu ua chrysarobin).
Yog tias koj tab tom nrhiav rau siab - zooChrysophanol hmoovcov chaw tsim khoom uas koj tuaj yeem tsim kom muaj sijhawm ntev -, kev sib koom tes ruaj khov, ces Shaanxi Medibridge Biotech Co., Ltd. yuav yog koj tus khub lag luam zoo tshaj plaws. Tsis txhob yig tiv tauj peb ntawmhi@medibridgeapi.com.
Cim npe nrov: chrysophanol hmoov, Tuam Tshoj chrysophanol hmoov manufacturers, lwm tus neeg, Hoobkas
