Sermorelin hmoov-tseem hu ua GHRH (1-29) lossis GRF(1-29)- yog N-terminal 29-amino-acid fragment ntawm tib neeg kev loj hlob hormone-tso cov tshuaj hormones, feem ntau muab raws li acetate ntsev nyob rau hauv cov hmoov dawb lyophilized. Nws xaiv ua rau GHRH receptors nyob rau hauv lub anterior pituitary, koom nrog cAMP/PKA txoj kev los txhawb pulsatile GH secretion thiab upstream modulation ntawm IGF-1 axis. Tsis zoo li GHRP chav kawm / ghrelin-receptor agonists, nws lub hom phiaj sib txawv receptor thiab kev taw qhia, uas pab cov kws tshawb fawb sib txawv cov txheej txheem hauv kev sim tsim.
Cov khoom no muaj nyob rau hauv cov khoom siv raw los yog ua ntej - puv lyophilized vials thiab tsim nyog rau kev tshawb fawb ntawm tes, thaum ntxov- kev tshawb fawb tsiaj, thiab kev txhim kho txoj kev. Raws li kev thov, peb muab cov kev pabcuam kuaj ntxiv nrog rau kev ua kom huv, cov ntsiab lus peptide, endotoxin, thiab cov kuab tshuaj seem. Raws li cov chaw tsim khoom lag luam sermorelin, Medibridge Biotech txhawb nqa ntau cov lag luam wholesale, hloov tau mg-ib -vial customization, daim ntawv lo / lub thawv xaiv, thiab npaj tau- rau- cov khoom xa tuaj kom luv sij hawm txhuas.
Rau kev tshaj tawm tam sim no lossis lub Hoobkas ncaj qha nrhiav kev tshawb fawb peptides, tiv tauj peb kom paub meej.
COA
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Khoom npe |
CAS Nr |
Batch Number |
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Sermorelin |
86168-78-7 |
MB2510091630 |
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Hnub tim tsim khoom |
Hnub Soj Ntsuam |
Hnub Kawg |
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2025-10-09 |
2025-10-10 |
2027-10-08 |
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Qauv Qty Base |
Ntim |
Txoj Kev Xeem |
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30.11 KWD |
100GS / lub raj mis |
HPLC |
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Yam khoom |
Txuj |
Cov txiaj ntsig |
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Purity |
Ntau dua lossis sib npaug li 98% |
99.17% |
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Peptide Assay |
Ntau dua lossis sib npaug li 80% |
91.80% |
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Loj Spectrum |
3357.93 |
3357.93 |
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Solubility |
Soluble hauv dej |
Ua raws |
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Clarity thiab xim ntawm kev daws |
Ntshiab thiab tsis muaj xim |
Ua raws |
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ntsev |
<5.0% |
1.34% |
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Dej |
Tsawg dua lossis sib npaug li 7.0% |
1.85% |
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Residual Solvent: Methanol |
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Tsawg dua lossis sib npaug li 0.3% |
0.0107% |
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Cov tshuaj acetonitrile |
Tsawg dua lossis sib npaug li 0.041% |
0.021% |
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Methylene Chloride |
Tsawg dua lossis sib npaug li 0.06% |
0.040% |
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N,N{0}}Dimethylformamide |
Tsawg dua lossis sib npaug li 0.088% |
N.D. |
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Triethylamine |
Tsawg dua lossis sib npaug li 0.032% |
N.D. |
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Tert -butyl methyl ether |
Tsawg dua lossis sib npaug li 0.5% |
0.249% |
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Endotoxin |
Tsawg dua lossis sib npaug li 0.5 EU / mg |
Ua raws |
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Microbial txwv |
Tag nrho cov kab mob aerobic<100 CFU/g Tag nrho cov poov xab & pwm<50 CFU/g |
<50 CFU/g <10 CFU/g |
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Cia |
Khaws rau hauv qhov chaw tsaus thiab txias qhuav (-20 txog 8 degree) |
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Xaus |
Cov batch ua raws li IN-HOUSE tus qauv |
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Specifications (rau kev tshawb fawb siv nkaus xwb)
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Daim ntawv |
Qauv Order |
Specification |
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Cov hmoov nyoos |
1 g |
Purity yog NLT 99% |
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Vials |
10 vials |
3ml / 5ml / 7ml / 15ml vials thiab lwm yam. |
Phau ntawv Snapshot
Sermorelinhmoovua rau GHRH receptors nyob rau hauv pituitary, ua rau cAMP/PKA signaling thiab txhawb pulsatile kev loj hlob hormone (GH) tso tawm. Qhov no ua rau kom nce IGF-1 ntau lawm hauv daim siab thiab ua rau txoj hauv kev qis qis anabolic. Hauv cov qauv ntawm tes thiab tsiaj txhu, qhov GH-IGF-1 axis no tau cuam tshuam nrog kev txhim kho cov protein synthesis (piv txwv li, AKT / mTOR), zoo dua nitrogen tshuav, lean pawg txhawb nqa, txhim kho cov roj metabolism, thiab kev hloov kho cov pob txha thiab pob txha mos xws li collagen, ALP, thiab aggrecan. Qee qhov kev tshawb fawb tseem tshawb txog GH surges thaum pw tsaug zog thiab yuav ua li cas circadian rhythms cuam tshuam rau cov txiaj ntsig ua piv txwv.
Kev Tshawb Fawb Txog Kev Tshawb Fawb
Sermorelin-Triven GH Txoj Kev
Sermorelin activates pituitary GHRH receptors los kho lub physiologic pulsatility ntawm kev loj hlob hormone tso tawm, ib tug atherosclerosis tseem ceeb rau downstream IGF-1 kev cai, kho cov ntaub so ntswg, thiab metabolic tshuav nyiaj li cas. Cov kev tshawb fawb tshawb fawb pom tau tias pulsatile GH zoo dua txhawb nqa cov protein synthesis, lipolysis, thiab insulin rhiab heev dua li qhov raug txuas mus ntxiv. Cov qauv no tso cai rau cov kws tshawb fawb los taug qab cAMP-GH-IGF-1 kev hloov pauv thoob plaws lub voj voog circadian thiab cov sijhawm ua piv txwv.
Pharmacokinetic–Pharmacodynamic (PK–PD) Kev nkag siab
Cov kev tshawb fawb ua ntej piav qhia txog Sermorelin ua luv luv - ua yeeb yam GHRH analog nrog ceev cov ntshav plasma tab sis muaj zog pharmacodynamic txuas rau GH pulses. Peak GH tso tawm feem ntau tshwm sim nyob rau hauv 15–30 feeb tom qab- kev tswj hwm, ua raws li kev nce qib hauv siab IGF-1 hauv ob peb teev. Lub sijhawm PK profile tso cai rau lub sijhawm meej-series sampling, ua rau nws zoo tagnrho rau kev ua qauv GH/IGF-1 tawm tswv yim thiab pulsatility dynamics. Kev sib piv PK-PD soj ntsuam nrog ntev GHRH analogs, xws li Tesamorelin, paub meej tias Sermorelin tsim cov ntse GH peaks thiab sai normalization, txhawb nws siv hauv kev siv tshuab thiab circadian-theem kev tshawb fawb.
Sermorelin vs Tesamorelin vs GHRP3
Cov Lus Qhia Txog Kev Tshawb Fawb
Targets GHRH receptors nyob rau hauv lub anterior pituitary. Ua kom lub cAMP/PKA teeb liab txoj kev. Txhawb nqa pulsatile GH secretion. Mimics natural GH rhythms. Siv hauv kev tshawb fawb, GH deficiency qauv, thiab tiv thaiv- kev tshawb fawb kev laus. Functional core fragment ntawm endogenous GHRH.Ua rau lub cev raug.
Kuj khi rau GHRH receptors, tab sis nrog txhim khu kev ruaj ntseg. Qhib tib txoj kev cAMP/PKA. Txhim kho IGF- 1 qib thiab txhim kho lipid metabolism. Pom zoo rau HIV-txog lipodystrophy hauv qee thaj tsam. Haum rau kev siv tshuaj kho mob. Ntev ib nrab -lub neej thiab ntau dua receptor affinity dua. Sermorelin.Often siv nyob rau hauv kho thiab translational kev tshawb fawb.
Ua kom lub PLC一 Ca²+ signaling pathway. Stimulates GH secretion ntawm ib tug txawv mechanism. Txhawb cov pob txha turnover thiab pob txha mos regeneration. Feem ntau siv hauv kev tshawb fawb txog metabolic thiab cov ntaub so ntswg kho .Tuaj yeem ua ke nrog Sermorelin rau kev sib koom ua ke ntawm kev ywj pheej ntawm GHRH txoj hauv kev.
FAQ
Q: Puas Sermorelin txo lub plab rog?
A: Txawm hais tias tsis yog tus neeg sawv cev lipolytic ncaj qha, Sermorelin qhov kev txhawb nqa ntawm GH thiab IGF-1 tuaj yeem cuam tshuam cov lipid metabolism hauv cov qauv kev tshawb fawb. Cov kev tshawb fawb qhia pom tias muaj roj oxidation zoo dua thiab cov cim ntshiv loj, tab sis cov teebmeem yog qauv -, koob tshuaj -, thiab sij hawm- nyob ntawm. Nws tsis yog qhov hnyav -cov tshuaj poob thiab yuav tsum tau txhais hauv cov txheej txheem txheej txheem.
Q: Leej twg yuav tsum zam peptides?
A: Hauv kev tshawb fawb, cov txheej txheem cais tawm tuaj yeem suav nrog cov qauv uas cuam tshuam GH axis, pituitary lesions, lossis hloov pauv receptor qhia. Rau kev txhais lus tseem ceeb, cov kev tshawb fawb feem ntau zam kev tsis sib haum xeeb xws li kev kho cov tshuaj hormones lossis cov teeb meem metabolic.
Q: Sermorelin puas tuaj yeem siv los ua qauv hnub nyoog- cuam tshuam txog kev poob qis hauv GH secretion?
A: Sermorelin feem ntau siv rau hauv kev laus -txoj kev tshawb fawb txog endocrine los simulate hypothalamic GHRH tso zis. Nws lub peev xwm los ua kom lub cev muaj zog GH pulses ua rau nws zoo tagnrho rau kev ntsuas pituitary teb, IGF-1 tawm tswv yim, thiab anabolic tsis kam hauv cov qauv laus.
Q: Sermorelin ua haujlwm sai npaum li cas?
A: Sermorelin induces GH tso tawm nyob rau hauv feeb ntawm kev tswj hwm, nrog rau cov ntshav siab GH qib feem ntau pom nyob ib ncig ntawm 15-30 feeb tom qab- txhaj tshuaj. Qhov pib sai no ua rau nws zoo tagnrho rau kev kawm pulsatile GH kinetics, lub sij hawm-sensitive sampling, thiab luv-lub sij hawm tawm tswv yim loops nyob rau hauv endocrine qauv.
Q: Puas yog peptides nyuaj rau koj lub siab?
A: Sermorelin nws tus kheej tsis yog hepatotoxic nyob rau hauv cov qauv kev tshawb fawb koob tshuaj. Qhov tseeb, nws txhawb cov kab mob siab IGF-1 ntau lawm. Txawm li cas los xij, lub siab ua haujlwm yuav tsum tau saib xyuas nyob rau hauv ntev - cov kev tshawb fawb, tshwj xeeb tshaj yog thaum ua ke nrog lwm cov tshuaj metabolic modulators lossis hauv cov qauv kab mob.
Q: Cov qauv piv txwv twg yog qhov zoo rau kev taug qab GH pulses tom qab kev tswj hwm Sermorelin?
A: Vim yog qhov ceev thiab ncua sij hawm ntawm GH tso tawm, nquag sampling (xws li, txhua txhua 10-20 feeb nyob rau 2-3 teev) yog pom zoo kom ntes lub siab tshaj plaws amplitude thiab mem tes zaus. Sijhawm- chav kawm ELISA lossis multiplex kev soj ntsuam feem ntau yog siv los ntsuas GH thiab IGF-1 dynamics.
Sermorelinhmoovtam sim no qhia tau hais tias muaj zog cog lus nyob rau hauv cov kev tshawb fawb ntawm kev loj hlob hormone physiology, IGF-1 kev cai, thiab metabolic modulation nyob rau hauv lub chaw kuaj mob. Yog tias koj tab tom nrhiav rau lub siab - cov chaw tsim khoom peptide zoo cog lus los tsim kev sib koom tes ntev thiab ruaj khov, thov hu rau peb ntawm: hi@medibridgeapi.com.
Cim npe nrov: sermorelin hmoov, Tuam Tshoj sermorelin hmoov manufacturers, lwm tus neeg, Hoobkas
