Kev piav qhia
Tirzepatide rau poob phaus yog ib tug dual insulinotropic receptor agonist nrog ob qho tib si qabzib muaj zog - txo qis thiab hnyav hnyav - muaj peev xwm poob, tus cwj pwm los ntawm qhov tsis tshua muaj kev pheej hmoo ntawm hypoglycemia thiab ntau yam txiaj ntsig cardiometabolic. Kev pib tsim nyog thiab nce ntxiv, ua tib zoo saib xyuas lub plab hnyuv siab raum, thiab kev hloov kho rau cov tshuaj sib xyaw ua ke yog qhov tseem ceeb rau nws daim ntawv thov kho mob. Hauv kev tswj qhov hnyav, qhov ntev - kev kho lub sij hawm ua ke nrog kev hloov kho txoj kev ua neej feem ntau yuav tsum tau los sib sau ua ke cov kev kho mob thiab txo qhov hnyav rov qab.
Raws li ib qho ntawm tsib lub tuam txhab tirzepatide saum toj kawg nkaus hauv Suav teb, Shaanxi Medibridge tuaj yeem muab tirzepatide nrog purity ntawm 99.988%, thaum lub purity ntawm cov chaw kuaj mob tsuas yog ncav cuag 99.4%. Qee qhov me me, qhov chaw kuaj tsis raug cai txawm tsim tirzepatide nrog qhov purity tsawg dua 98%.
COA
|
Yam khoom |
Txuj |
Cov txiaj ntsig |
|
Purity |
Ntau dua lossis sib npaug li 98% |
99.986% |
|
Peptide Assay |
Ntau dua lossis sib npaug li 80% |
95.12% |
|
Loj Spectrum |
4813.45 ± 0.5 |
4813.21 |
|
Ib ntus |
Tyr-{Aib}-Glu-Gly-Thr-Ph-Thr-Ser-Asp-Tyr- Ser-Ile-{Aib}-Leu-Asp-Lys-Ile-Ala-Gln-{diacid{19}} gamma-Glu-(AEEA)2-Lys}-Ala-Phe-Val-Gln- Trp-Leu-Ile-Ala-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro{{40}H2}Pro{{40}S2} |
Kev sib tw |
|
Qhov tshwm sim |
Dawb hmoov zoo |
Ua raws |
|
Solubility |
Soluble hauv dej |
Ua raws |
|
Clarity thiab xim ntawm kev daws |
Ntshiab thiab tsis muaj xim |
Ua raws |
|
PH |
6.0 – 9.0 |
7.74 |
|
Sodium ion |
Tsawg dua lossis sib npaug li 3.0% |
1.33% |
|
Dej |
Tsawg dua lossis sib npaug li 10.0% |
1.09% |
|
Residual Solvent: Methanol Isopropanol Acetonitrile Methylene Chloride N,N{0}}Dimethylformamide Triethylamine Tert -butyl methyl ether |
||
|
Tsawg dua lossis sib npaug li 0.3% |
0.0066% |
|
|
Tsawg dua lossis sib npaug li 0.5% |
N.D. |
|
|
Tsawg dua lossis sib npaug li 0.041% |
0.019% |
|
|
Tsawg dua lossis sib npaug li 0.06% |
0.028% |
|
|
Tsawg dua lossis sib npaug li 0.088% |
N.D. |
|
|
Tsawg dua lossis sib npaug li 0.032% |
N.D. |
|
|
Tsawg dua lossis sib npaug li 0.5% |
0.130% |
|
|
Endotoxin |
Tsawg dua lossis sib npaug li 5 EU / mg |
0.08 EU / mg |
|
Microbial Txwv |
Tag nrho cov kab mob aerobic<100 CFU/g Total yeast & mold <50 CFU/g |
<50 CFU/g <10 CFU/g |
|
Cia |
Khaws rau hauv qhov chaw tsaus thiab txias qhuav (-20 txog 8 degree) |
|
|
|
||
Specifications (rau kev tshawb fawb siv nkaus xwb)
|
Daim ntawv |
Qauv Order |
Specification |
|
Cov hmoov nyoos |
1 g |
Purity yog NLT 99.96% |
|
Vials |
10 vials |
3ml / 5ml / 7ml / 15ml vials thiab lwm yam. |
Kev Tshawb Fawb
Cardiovascular Outcomes Overview
Tirzepatide Cardiovascular Outcomes Overview (SURPASS-CVOT) Daim duab no qhia txog cov kev tshawb pom thawj zaug thiab tseem ceeb thib ob los ntawm SURPASS-CVOT. Tirzepatide tau ntsib tsis muaj kev cuam tshuam rau dulaglutide rau MACE-3 (HR 0.92; CI suav nrog 1.0), nrog kev txo qis tseem ceeb hauv txhua qhov kev tuag (HR 0.84). Cheebtsam ntawm MACE-3 suav nrog kev tuag ntawm cov hlab plawv, tsis tuag MI, thiab mob stroke tsis txaus. Kev txhais lus yog kev tshawb fawb-taw qhia: cov teeb liab thib ob yog qhov kev xav-tsim thiab yuav tsum tau muab cov ntsiab lus nrog rau tag nrho cov kev sim thiab kev txheeb xyuas hierarchies. Rau kev tshawb nrhiav pom nkaus xwb.
Pharmacokinetics: Ib Nrab Lub Neej thiab Kev Siv Tshuaj Txhua Lub Limtiam
Qhov schematic no qhia txog tirzepatide's PK profile txhawb kev tswj hwm subcutaneous ib zaug ib lim tiam. Qhov kwv yees li ib nrab-lub neej ntawm ~ 5 hnub thiab albumin khi ua rau muaj kev cuam tshuam cuam tshuam thoob plaws lub sijhawm noj tshuaj thiab kev ua kom ruaj khov nyob rau hauv kwv yees li plaub lub lis piam. Qhov nkhaus yog qhov piv txwv (tsis yog ntsuas) thiab npaj los qhia qhov kev sib tw noj ntau dua li qhov tseeb. Siv rau kev kawm sib tham ntawm qhov rais piv txwv, qauv qhia txog kev noj tshuaj, thiab kev npaj rau kev cuam tshuam- teb. Rau kev tshawb nrhiav pom nkaus xwb; tsis yog rau kev txiav txim siab kho mob.
Cardiometabolic Profile: Biomarkers hauv SURPASS
Biomarkers hauv SURPASS Lub vaj huam sib luag no qhia txog ntau qhov kev pheej hmoo-yam hloov pauv tau pom nyob thoob plaws SURPASS kev sim. Kev txo qis hauv HbA1c (txog ~ -2.4%), lub cev qhov hnyav, systolic ntshav siab, thiab triglycerides, nrog rau cov kev hloov pauv hauv HDL thiab albuminuria, ua ke nrog kev ua haujlwm zoo nrog kev txo qis ntawm cardiometabolic. Cov nyhuv loj sib txawv raws li koob tshuaj, pej xeem, thiab kev kawm tsim; cov duab yog piav qhia thiab tsis suav nrog kev kwv yees. Txhais biomarker hloov raws li kev txhawb nqa cov ntsiab lus es tsis yog pov thawj ntawm kev txo qis hauv plawv. Rau kev tshawb nrhiav pom nkaus xwb.
PK: Ntau-Khoom noj kom ruaj khov
Cov kab ntau lawm PK daim duab qhia txog qhov ncov-trough profiles nrog kev txhaj tshuaj txhua lub limtiam thiab nce zuj zus mus rau lub xeev ruaj khov los ntawm kwv yees li Lub Limtiam 4. Cov lus ceeb toom ntawm t1/2 (~ 5 hnub), Cmax, thiab Ctrough hais txog kev tiv thaiv kev tiv thaiv thoob plaws lub sijhawm interdose. Cov ntaub ntawv zoo li no muaj txiaj ntsig zoo rau kev npaj PK / PD sampling, nonlinear mix-effects modeling, thiab nkag siab txog concentration-dependent tolerability. Curve shape thiab magnitude yog schematic thiab tsis scale. Rau kev tshawb nrhiav pom nkaus xwb; tsis yog rau kev txiav txim siab kho mob.
Kev Tshawb Fawb
Tirzepatide rau poob phausyog ib tug dual GIP/GLP-1 receptor agonist uas ua kom muaj kev noj qab haus huv, txo qhov hnyav npaum li cas (~ 15-21% ntawm 72 lub lis piam hauv cov neeg laus uas tsis muaj ntshav qab zib) nrog rau kev txhim kho cov cim cardiometabolic. Cov lus qhia tseem ceeb ntawm kev tshawb fawb muaj xws li kev kwv yees ntawm cov lus teb thiab kev kam rau siab (biomarkers, phenotypes), cov tswv yim rau kev saib xyuas thiab kev ua raws, kev siv tshuab txuas rau visceral adiposity thiab hepatic steatosis, thiab kev sib piv ntev ntev thiab kev nyab xeeb piv rau lwm cov kev kho mob incretin.
Kev txhawj xeeb-dawb Tom qab-Kev Pabcuam muag
Raws li tus neeg muag khoom muaj txiaj ntsig zoo peptide, Shaanxi Medibridge tsis tsuas yog muab siab - zoo, siab - purity Tirzepatide, tab sis kuj txhawb kev sim rau txhua qhov kev txiav txim muab tso los ntawm cov neeg siv khoom tshiab thiab tam sim no. Txhua pawg ntawm peb cov khoom peptide tuaj nrog Daim Ntawv Pov Thawj Tso Cai (COA) muab los ntawm peb lub chaw kuaj mob. Yog tias qhov ua tau zoo tsis ua raws li cov qauv, peb yuav ris txhua qhov kev poob (nrog rau tab sis tsis txwv rau cov nqi thauj khoom, nqi khoom, nqi kuaj, thiab lwm yam).
Tsis tas li ntawd, Shaanxi Medibridge kuj txhawb kev txiav txim rau cov hmoov nyoos hauv kilogram kom muaj nuj nqis. Peb kuj txhawb kev txiav txim siab rau txhua lub vials npaj rau kev tshawb fawb siv.
FAQ
Q: Cov khoom puas tuaj yeem ncav cuag 99%?
A: Peb lav tag nrho cov purity ntawm peb cov khoom kom siab tshaj 99.98% thiab txhawb Chromate thiab Janoshik kuaj.
Q: Koj puas tuaj yeem lav cov ntsiab lus peptide txaus?
A: Tau kawg. Qee zaum, vim qhov tsis tiav ntawm cov khoom lag luam Vials thaum rov kuaj dua, tej zaum yuav muaj qhov yuam kev me ntsis hauv cov ntsiab lus peptide ntawm cov txiaj ntsig rov qab, feem ntau nyob ib ncig ntawm ± 0.5mg.
Q: Koj puas muaj endotoxin tswj?
A: Tau kawg. Peb kuj txhawb cov neeg siv khoom hauv kev muab kev kuaj ntxiv rau endotoxins / hnyav hlau, thiab lwm yam.
Q: Shipping thiab cia khoom?
A: Peb yuav xa los ntawm FedEx / UPS / DHL. Tom qab tuaj txog, cov khoom yuav tsum tau muab khaws cia ntawm −20 degree, tiv thaiv los ntawm lub teeb thiab nyob rau hauv ib qho chaw qhuav, tsis txhob rov qab khov -thaw cycles ntau li ntau tau.
Q: Reconstitution thiab siv cov lus pom zoo?
A: Ua ntej- yaj hauv dej tsis huv lossis PBS; Yog tias tsim nyog, ntxiv 0.1-1% HSA / BSA kom txo qis adsorption; lim ntawm 0.22 μm raws li xav tau; Khaws ntawm -20℃tom qab aliquoting.
Q: Lub sij hawm xa tuaj, xaj kom muaj nuj nqis, thiab nqe?
A: Hauv - cov khoom xa tuaj hauv 2 hnub ua haujlwm; bulk pricing yog negotiable.
Q: Scope ntawm daim ntawv thov thiab ua raws?
A: Rau kev tshawb fawb siv nkaus xwb (RUO). Kev txwv nruj rau tib neeg kev kuaj mob thiab kev kho mob. Yog tias tsis yog - pom tias ua raws, peb muaj cai rov qab thiab tsis kam xa daim ntawv xaj.
Tam sim no,Tirzepatide rau poob phausyog ib qho chaw zoo heev ntawm kev tshawb fawb hauv kev tswj cov ntshav qabzib. Yog tias koj tam sim no tab tom nrhiav rau siab -cov chaw tsim khoom peptide zoo uas koj tuaj yeem muaj lub sijhawm ntev -, kev koom tes ruaj khov, thov hu rau peb ntawm hi@medibridgeapi.com.
Cim npe nrov: Tirzepatide rau poob phaus, Tuam Tshoj tirzepatide rau poob phaus manufacturers, lwm tus neeg, Hoobkas
