Epithalon hmoovyog ib tug synthetically tsim luv luv peptide (tetrapeptide) nrog rau cov amino acid sequence Ala-Glu-Asp-Gly (abbreviated AEDG), tshuaj lub npe H-Ala-Glu-Asp-Gly-2} mocular formula C4, 390.35 Nws.
Nws pib los ntawm lub tswv yim ntawm ib qho active fragment ntawm thaum ntxov pineal gland extract (Epithalamin) thiab yog siv los ua ib qho cuab yeej siv rau kev kawm "kev laus biology, telomeres / telomerase, circadian rhythms, thiab antioxidant pathways."
Trust Shaanxi Medibridge rau qib kev tshawb fawb zoo tshaj Epithalon (AEDG). Raws li tus neeg muag khoom peptide siab, peb xa ntau dua lossis sib npaug rau 99.6% purity (HPLC-tsim pov thawj) lyophilized hmoov nrog ntau cov COA, MS / HPLC cov ntaub ntawv, thiab kev tswj tsis huv. Muaj los ntawm milligram mus rau tej, nrog kev cai ntim thiab ceev ceev thoob ntiaj teb shipping.
COA
|
|
||
|
Khoom npe |
CAS Nr |
Batch Number |
|
Epithalon |
307297-39-8 |
MB2510151853 |
|
Hnub tim tsim khoom |
Hnub Soj Ntsuam |
Hnub Kawg |
|
2025-10-15 |
2025-10-16 |
2027-10-14 |
|
Qauv Qty Base |
Ntim |
Txoj Kev Xeem |
|
2.53 KWG |
50 Gs / COJ |
HPLC |
|
Yam khoom |
Txuj |
Cov txiaj ntsig |
|
Purity |
Ntau dua lossis sib npaug li 98% |
99.65% |
|
Peptide Assay |
Ntau dua lossis sib npaug li 80% |
90.52% |
|
Loj Spectrum |
390.35 |
390.35 |
|
Solubility |
Soluble hauv dej |
Ua raws |
|
Clarity thiab xim ntawm kev daws |
Ntshiab thiab tsis muaj xim |
Ua raws |
|
Sodium ntsev |
<5.0% |
1.15% |
|
Dej |
Tsawg dua lossis sib npaug li 7.0% |
3.51% |
|
Residual Solvent: |
||
|
Methanol |
Tsawg dua lossis sib npaug li 0.3% |
Ua raws |
|
Isopropanol |
Tsawg dua lossis sib npaug li 0.5% |
0.127% |
|
Cov tshuaj acetonitrile |
Tsawg dua lossis sib npaug li 0.041% |
0.023% |
|
Methylene Chloride |
Tsawg dua lossis sib npaug li 0.06% |
0.026% |
|
N,N{0}}Dimethylformamide |
Tsawg dua lossis sib npaug li 0.088% |
Ua raws |
|
Triethylamine |
Tsawg dua lossis sib npaug li 0.032% |
Ua raws |
|
Tert -butyl methyl ether |
Tsawg dua lossis sib npaug li 0.5% |
0.264% |
|
Endotoxin |
Tsawg dua lossis sib npaug li 0.5 EU / mg |
Ua raws |
|
Microbial txwv |
Tag nrho cov kab mob aerobic<100 CFU/g Tag nrho cov poov xab & pwm<50 CFU/g |
<50 CFU/g <10 CFU/g |
|
Cia |
Khaws rau hauv qhov chaw tsaus thiab txias qhuav (-20 txog 8 degree) |
|
|
Xaus |
Cov batch ua raws li IN-HOUSE tus qauv |
|
|
|
||
Specifications (rau kev tshawb fawb siv nkaus xwb)
1.High purity: HPLC Ntau dua los yog sib npaug rau 99.6%, ESI-MS txheeb xyuas, zoo heev sib xws
2.Lyophilized acetate ntsev: tsawg noo noo / tsawg residual kuab tshuaj; tswj impurity profile
3.Accurate quantification: calibrated net peptide cov ntsiab lus nrog counterion/moisture kho kom meej formulation
4.Ua tiav cov ntaub ntawv: CoA, HPLC/UPLC chromatograms, MS, Karl Fischer ya raws thiab counterion qhia
5.Txoj kev xaiv: xaiv kev kuaj endotoxin, 0.22 μm pom, thiab kev pabcuam aliquoting
6.Supply & support: mg–kg scale customization, sai sai, technical thiab kev txhawb nqa
|
Daim ntawv |
Qauv Order |
Specification |
|
Cov hmoov nyoos |
1 g |
Purity yog NLT 99.65% |
|
Vials |
10 vials |
3ml / 5ml / 7ml / 15ml vials thiab lwm yam. |
Tshawb nrhiav kev pom zoo thiab kev xav
Telomerase Axis (Cov txheeb ze pom zoo)
Kev pom zoo pom
Thoob plaws ntau lub hauv paus thiab cov neeg laus- tau los ntawm cov xovtooj ntawm tes thiab hauv cov qauv tsiaj txhu, kev ua haujlwm telomerase tau nce siab, tus nqi ntawm telomere attrition txo qis, thiab hauv qee lub tshuab telomere elongation yog pom. Cov kev hloov pauv no yog nrog los ntawm kev txhim kho hauv cov cim cim cim npe (xws li, txo SA-gal staining thiab txo qis p16INK4a signaling).
Cov txheej txheem yooj yim
a. Transcriptional upregulation ntawm TERT koom nrog c-Myc/E-box thiab Sp1 khi qhov chaw, ua ke rau hauv zos epigenetic xwm txheej (promoter DNA methylation thiab histone acetylation).
b. Cov teebmeem Antioxidant uas txo qis ROS-mediated telomeric kev puas tsuaj (qis 8-OHdG), yog li tiv thaiv telomeres ncaj qha.
c. Cov ntawv ceeb toom txwv tsis pub qhia txog kev hloov pauv ntawm cov chaw nyob, tshwj xeeb yog TRF1/TRF2.
Cov pov thawj ciam teb
Cov teebmeem yog hom cell-hom thiab lub xeev nyob ntawm, nrog kev sib txawv ntawm qhov chaw kuaj ntshav rov ua dua tshiab; qhov kev taw qhia ntawm kev cuam tshuam hauv cov qog lossis cov hlwb premalignant tseem tsis tau daws.
Circadian Rhythm / Pineal-Endocrine Axis
Kev pom zoo pom
Hauv cov qauv tsiaj thiab me me -kev tshawb fawb tib neeg nrog Epithalon hmoov, nocturnal melatonin secretion atherosclerosis thiab amplitude tshwm tuaj; pw tsaug zog architecture thiab ob qho tib si subjective thiab lub hom phiaj pw tsaug zog zoo yog optimized. Lub moos Peripheral-gene (CLOCK/BMAL1, PER/CRY) qhia cov suab sib txawv mus rau qhov profile hluas dua.
Cov txheej txheem yooj yim
a. Kev tswj hwm sab sauv ntawm pineal npaum li cas- txwv tsis pub cov enzymes (AA-NAT, HIOMT) hauv kev qhia thiab kev ua si, rov qab kho SCN-pineal axis synchrony.
b. Fine-tuning ntawm transcription–translation feedback loop (TTFL) ob theem thiab amplitude.
c. Ua raws li endogenous-zoo li ultrashort-peptide teeb liab, cuam tshuam rau neuro-endocrine-immune network coupling.
Cov ntawv sau tseg
Multimodal validation tuaj yeem ua ke tso zis 6-sulfatoxymelatonin excretion, actigraphy, thiab peripheral- ntshav moos-gene transcription rhythms.
Antioxidant thiab Mitochondrial Homeostasis (cov ntaub ntawv pov thawj dav dav)
Consensus Observations:Upregulation ntawm antioxidant enzymes (SOD, CAT, GPx); txo cov lipid peroxidation cov cim (MDA, 4-HNE) thiab DNA oxidative puas (8-OHdG); txhim kho mitochondrial membrane peev xwm (ΔΨm) thiab ua pa ua pa.
Cov txheej txheem yooj yim
a. Kev ua kom muaj Nrf2-ARE txoj hauv kev (upregulating HO-1, NQO1, GCLC) nrog concurrent suppression of NOX-mediated ROS production.
b. Kev txhawb nqa ntawm mitochondrial biogenesis thiab kev tswj kom zoo (PGC-1 / NRF1 / TFAM), nrog rau kev txhim kho autophagy / mitophagy.
Cov ntawv sau tseg
Ib qho kev nyeem ntawv ua ke tau pom zoo, suav nrog Seahorse extracellular flux assays rau mitochondrial respiration, ROS probes, GSH / GSSG ratio, thiab Nrf2 nuclear translocation.
Antioxidants thiab Mitochondrial Homeostasis (Cov pov thawj zoo sib xws)
Kev pom zoo pom
Upregulation ntawm antioxidant enzymes xws li SOD, CAT, thiab GPx txo lipid peroxidation (MDA / 4-HNE) thiab DNA oxidative puas (8-OHdG), txhim kho mitochondrial membrane muaj peev xwm thiab ua pa ua pa.
Muaj peev xwm Mechanisms
a. Ua kom Nrf2-YOG txoj hauv kev (kev tswj hwm ntawm HO-1/NQO1/GCLC, thiab lwm yam), inhibiting NOX-related ROS tiam;
b. Txhawb nqa ntawm mitochondrial biogenesis thiab kev tswj kom zoo (PGC-1 / NRF1 / TFAM, nruab nrab txhim kho autophagy / mitochondrial autophagy).
Tshawb nrhiav tswv yim
Nws raug nquahu kom siv mitochondrial respiratory flux (Seahorse), ROS probes, GSH / GSSG ratio, thiab Nrf2 nuclear translocation raws li kev nyeem ua ke.
Inflammation and Immune Homeostasis (Supported by Multiple Models, Heterogeneity Exists)
Observed Signals
Txo cov pro-mob mob xws li TNF- /IL-6/IL-1 , upregulated IL-10; Qee cov tsiaj txhu thiab cov qauv hauv vitro tau pom tias muaj kev txhim kho thymic qauv thiab T cell muaj nuj nqi ntsuas.
Muaj peev xwm Mechanisms
a. Inhibition ntawm NF-κB p65 nuclear translocation, stabilization ntawm IκB, thiab txo cov COX-2/NO synthesis txoj kev ua;
b. Kev txo qis ntawm kev mob aseptic mob ntev los ntawm kev txo qis qis dua -associated secretory phenotype (SASP).
Tshawb nrhiav tswv yim
Ua tib zoo cuam tshuam nrog telomere / oxidative kev ntxhov siab axis, cov saw caj dab yuav tsum tau sib txawv ntawm lub sijhawm.
Kev Tshawb Fawb Tsim thiab Kev Pom Zoo Pom Zoo (Rau Kev Sib Pauv Kev Kawm Tsuas)
Telomeric Axis: TRAP kev ua, TERT mRNA/protein, qPCR telomere length, shelterin expression, Chip-qPCR (TERT promoter histone markers).
Circadian Rhythm: Peripheral blood CLOCK/BMAL1/PER1/2 transcription amplitude and phase, zis 6-sulfate oxidized melatonin, carpal kinesiology/polysomnography.
Antioxidant/Mitochondria: ROS probes, MDA/8-OHdG, GSH/GSSG, Seahorse respiration, ΔΨm, Nrf2-ARE reporter.
Inflammation/Immunity: NF-κB kev ua, IκB stability, cytokine profile, T cell phenotype thiab muaj nuj nqi.
Kev laus/Kev Kho: SA- -gal, p16/p21, -H2AX, comet assay, autophagy/mitochondrial autophagy markers (LC3-II/PINK1-Parkin).
FAQ
Q: Lub luag haujlwm ntawm Epitalon / Epitalon yog dab tsi?
A: Ib qho hluavtaws tetrapeptide (AEDG) siv los ua kev tshawb fawb soj ntsuam; Cov cim qhia hauv cov kev tshawb fawb txog kev kho mob thiab cov tib neeg me me suav nrog telomere / telomerase modulation, circadian / melatonin txhawb nqa, thiab antioxidant-mitochondrial homeostasis.
Q: Puas Epitalon txhim kho daim tawv nqaij?
A: Nyob rau hauv vitro / tsiaj cov ntaub ntawv qhia txo oxidative kev nyuaj siab / MMPs thiab txhim kho cov cim collagen; Cov pov thawj kho mob tsuas yog txwv thiab tsis suav nrog.
Q: Puas yog Epitalon nce testosterone?
A: Tsis muaj pov thawj zoo sib xws ntawm testosterone nce. Cov teebmeem endocrine tau tshaj tawm feem ntau cuam tshuam nrog kev tswj hwm melatonin / circadian, tsis yog androgens.
Q: Puas yog Epitalon FDA pom zoo?
A: Tsis yog. Nws tsis pom zoo los ntawm FDA / EMA / NMPA; feem ntau muab raws li kev tshawb fawb reagent nkaus xwb.
Q: Nws siv sijhawm ntev npaum li cas los ua haujlwm?
A: Tus qauv-dependent: redox / mitochondrial nyeem ntawv tuaj yeem hloov pauv hauv cov xuab moos-hnub; circadian endpoints feem ntau 1-4 lub lis piam; telomere / tertometrics xav tau ntev dua (lub lis piam-hli).
Q: Puas yog Shaanxi Medibridge Biotech Co., Ltd. yog lub chaw tsim khoom peptide?
A: Yog, peb yog GMP- tswj peptide chaw tsim tshuaj paus, thiab peb tuaj yeem muab cov kev daws teeb meem rau ntau yam peptides.
Peb tau cog lus los muab cov khoom lag luam ruaj khov thiab txhim khu kev qha, traceable source, thiab kev txhawb nqa ceev ceev kom ntseeg tau tias kev ua haujlwm zoo ntawm koj qhov kev sim. Yog tias koj tab tom nrhiav ib qhoEpithalon hmoovcov chaw tsim khoom, thov hu rau peb tam sim ntawm hi@medibridgeapi.com lossis WhatsApp: +44 07548632075.
Cim npe nrov: Tuam Tshoj epithalon hmoov manufacturers, lwm tus neeg, Hoobkas
