DSIP Peptide hmoovyog suav hais tias yog endogenous regulator ntawm qeeb-wave pw (SWS/δ zog). Cov ntaub ntawv pov thawj qhia tias nws muaj ntau- lub hom phiaj, qis- kev cuam tshuam neuromodulatory cuam tshuam, cuam tshuam rau gabanergic, serotonergic, noradrenergic, thiab HPA axis systems.
Ntawm Shaanxi Medibridge, peb tsim cov ntaub ntawv tshawb fawb-siv peptide nrog cov qauv tsim-thiab-kev lag luam, ua haujlwm rau cov koom haum thiab cov chaw sim biotech thoob ntiaj teb. Peb xa cov kev cai ua ntu zus los ntawm milligram mus rau ntau-gram nplai nrog QC nruj thiab ntau qhov tshwj xeeb COAs. Rau DSIP (Delta Pw tsaug zog-Inducing Peptide), peb muab cov khoom ntawm ntau dua lossis sib npaug rau 99.68% purity, lees paub los ntawm HPLC/MS. Suav rau cov sij hawm ua cov khoom lag luam txhim khu kev qha, hloov tau cov specs, thiab kev txhawb nqa los ntawm kev nug txog kev xa khoom, ntxiv rau kev ntim khoom.
COA
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Khoom npe |
CAS Nr |
Batch Number |
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Dsip peptide hmoov |
62568-57-4 |
MB2510231457 |
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Hnub tim tsim khoom |
Hnub Soj Ntsuam |
Hnub Kawg |
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2025-10-23 |
2025-10-24 |
2027-10-22 |
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Qauv Qty Base |
Ntim |
Txoj Kev Xeem |
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8 00.52 TZS |
10GS / lub raj mis |
HPLC |
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Yam khoom |
Txuj |
Cov txiaj ntsig |
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Purity |
Ntau dua lossis sib npaug li 98% |
99.68% |
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Peptide Assay |
Ntau dua lossis sib npaug li 80% |
87.82% |
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Loj Spectrum |
848.82 |
848.82 |
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Solubility |
Soluble hauv dej |
Ua raws |
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Clarity thiab xim ntawm kev daws |
Ntshiab thiab tsis muaj xim |
Ua raws |
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Sodium ntsev |
<5.0% |
1.88% |
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Dej |
Tsawg dua lossis sib npaug li 7.0% |
2.31% |
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Residual Solvent: |
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Methanol |
Tsawg dua lossis sib npaug li 0.3% |
Ua raws |
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Isopropanol |
Tsawg dua lossis sib npaug li 0.5% |
Ua raws |
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Cov tshuaj acetonitrile |
Tsawg dua lossis sib npaug li 0.041% |
0.027% |
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Methylene Chloride |
Tsawg dua lossis sib npaug li 0.06% |
0.035% |
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N,N{0}}Dimethylformamide |
Tsawg dua lossis sib npaug li 0.075% |
Ua raws |
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Triethylamine |
Tsawg dua lossis sib npaug li 0.029% |
Ua raws |
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Tert -butyl methyl ether |
Tsawg dua lossis sib npaug li 0.5% |
0.187% |
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Endotoxin |
Tsawg dua lossis sib npaug li 0.5 EU / mg |
Ua raws |
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Microbial txwv |
Tag nrho cov kab mob aerobic<100 CFU/g Tag nrho cov poov xab & pwm<50 CFU/g |
<50 CFU/g <10 CFU/g |
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Cia |
Khaws rau hauv qhov chaw tsaus thiab txias qhuav (-20 txog 8 degree) |
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Xaus |
Cov batch ua raws li IN-HOUSE tus qauv |
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Hniav Profile & Fragrance Role
1. Peb qhov kev tshawb fawb-siv DSIP peptide muaj ntau dua lossis sib npaug rau 99.68% purity.
2. Txheeb xyuas los ntawm HPLC nrog LC-MS tus kheej.
3. Ntau yam tshwj xeeb COAs rau kev txhim khu kev qha batch sib xws.
4. Customizable specs (tsim daim ntawv, davhlau ya nyob twg capping, aliquots.
5. Ntim); scalable mov los ntawm mg rau multi-gram.
6. Txhawb kev txhawb nqa los ntawm kev nug txog kev xa khoom.
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Daim ntawv |
Qauv Order |
Specification |
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Cov hmoov nyoos |
1 g |
Purity yog NLT 99.68% |
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Vials |
10 vials |
3ml / 5ml / 7ml / 15ml vials thiab lwm yam. |
Mechanism ntawm Action
Network-level Effect (Rau Kev Kawm/Kev Tshawb Fawb Tsuas)
DSIPpeptide hmoovnce NREM delta lub zog los ntawm kev txhawb nqa loj - nplai synchrony ntawm cortical UP/DOWN xeev thiab tso cai thalamic tawg hom. Kev tswj hwm tshuaj hauv nruab nrab / kev tshawb fawb pom hauv luav thiab nas: Schoenenberger li al. thawj zaug cais cov uas tsis yog-peptide cyclic nonapeptide nrog "δ-EEG li" los ntawm luav cerebral venous ntshav; intraventricular kev tswj hwm tau nce delta nthwv dej thiab txhawb kev pw tsaug zog hauv luav, uas yog ib qho ntawm cov pov thawj ncaj qha tshaj plaws.
Ua haujlwm tau zoo, nws zoo li txo qis qhov kev xav tau ntawm kev sawv- txhawb nqa nuclei (LC, TMN, DR), tso cai rau VLPO- muab GABA / galanin inhibition los ua tus thawj. Cov txiaj ntsig tau yog qhov sib sib zog nqus qeeb-yoj kev ua haujlwm nrog kev khaws cia hauv vaj tse es tsis yog lub ntiaj teb sedation. Cov teebmeem muaj zog tshaj thaum pw tsaug zog homeostatic tam sim no (post-deprivation los yog lig lom hmo ntuj).
Tej kev siv
Neurotransmitter System Modulation (Tsis muaj zog, Ntau -lub hom phiaj)
Kev kos npe zoo tshaj plaws yog kev hloov pauv me me rau cov suab nrov inhibitory: Cov ntaub ntawv no muaj ib feem los ntawm cov ntaub ntawv tshawb fawb tau muab rau pej xeem los ntawm National Library of Medicine (NLM). Kev yooj yim yooj yim ntawm GABAergic kis tau tus mob thiab txo catecholaminergic tsav. DSIP yog txuam nrog damped locus coeruleus noradrenergic tso zis, ib tug hloov maj mam normalization ntawm serotonergic signaling (tsawg dua 5-HT2A-xws li cortical excitation), thiab qis dua glutamatergic tso tawm qhov tshwm sim nyob rau hauv wake circuits. Cov kev hloov no yog tsawg-amplitude thiab cov ntsiab lus nyob ntawm seb, raws li ib tug neuromodulatory "teeb" -taw tes" hloov es tsis yog ib tug receptor-saturating yeeb tshuaj.
Cellular thiab synaptic hypotheses (Rau Kev Kawm/Kev Tshawb Fawb Tsuas)
DSIP's Trp- muaj, hloov tau cov qauv nonapeptide thiab acidic residues qhia txog kev sib cuam tshuam ntawm daim nyias nyias uas tuaj yeem hloov kho receptor/channel microenvironments. Nyob rau theem Circuit Court, txo NE/cAMP suab nrov nyiam thalamic T-hom Ca2+ channel tawg npaj txhij thiab cortical qeeb oscillations. Synaptically, cov pov thawj taw qhia rau qhov txo qis me me hauv kev tso tawm qhov tshwm sim thiab qhov nce me me hauv inhibitory kev ua tau zoo, txhim kho E / I tshuav nyiaj li cas rau qeeb -wave synchronization.
Qhov nws yuav tsis yog DSIP tsis coj zoo li melatoninergic theem shifter, classic benzodiazepine/GABA-A agonist, los yog orexin receptor antagonist. Pw tsaug zog theem proportions thiab spindle architecture feem ntau yog khaws cia, nyiam "NREM tob" tshaj "kev xav dav dua."
Cov ntawv nyeem pom zoo suav nrog N3 lub sijhawm, SWA qhov ceev thiab txoj kab nqes, SO-spindle coupling metrics, HRV vagal indices thaum ntxov NREM, thiab salivary / serum cortisol tiam sis nyob rau hauv kev ntxhov siab. Ua ke, cov no tsim lub hom phiaj pharmacodynamic ntiv tes txawv ntawm sedative hypnotics.
Analytical Test thiab Methodology
Immunometry
RIA/ELISA raug cuam tshuam los hla -reactivity thiab matrix cuam tshuam, ua rau nws tsim nyog rau kev tshuaj ntsuam ntau dua li cov qauv kub.
Pawg Spectrometry
LC-MS/MS yog txoj kev nyiam. ruaj khov isotope-labeled cov qauv sab hauv, khoom-theem extraction rau desalting, thiab qis- adsorption consumables yog pom zoo. Ua tib zoo saib rau Trp oxidation (+16 Da) thiab deamidation artifacts.
Electroencephalography
Feem ntau siv delta zog ceev, N3 ntev, thiab qeeb yoj ceev / nqes hav; ua ke nrog kev ntsuam xyuas cov ntsiab lus (PSQI / ISI) thiab cov kev ntsuam xyuas lub hom phiaj diurnal (MSLT / alertness task).
Receptor Kev Tshawb Fawb
Photoaffinity probes (xws li, diazepine/benzophenone-hloov DSIP) + membrane protein enrichment + proteomics, los yog genome-kev tshuaj ntsuam CRISPR thoob plaws tuaj yeem siv los txheeb xyuas qhov tseem ceeb.
Cov ntsiab lus tseem ceeb ntawm kev sim tsim & Cov Pitfalls
1. Kev sim pw tsaug zog (tus qauv nas): Kev tswj kom nruj circadian atherosclerosis, lub tawb ib puag ncig thiab kev hloov mus rau hmo ntuj yuav tsum tau ua. Ntau- hmo ntuj puag thiab hla-randomization tau siv los txo qhov sib txawv ntawm tus kheej.
2. EEG spectrum tsom xam ua ntej- kev sau npe thiab kho ntau qhov sib piv; Paub qhov txawv ntawm "cov nyhuv rov qab" ntawm SWA ntawm kev pw tsaug zog deprivation.
3. Kev tswj hwm thiab txoj hauv kev: Intranasal tswj yuav tsum muaj cov qauv tshuaj tsuag qhov loj me, lub cev thiab lub sijhawm nyob. iv/sc yuav tsum tau coj mus rau hauv tus account qhov cuam tshuam ntawm tus nqi propulsion ntawm CNS nyhuv.
4. Kev txheeb cais thiab rov ua dua: Cov txiaj ntsig tsis tseeb yog qhov tshwm sim hauv cov qauv me me; Nws raug nquahu kom siv Bayesian / hierarchical qauv thiab qhia txog qhov loj me thiab kev ntseeg siab ntawm lub sijhawm, thiab txhawb nqa ntau -center reproduction.
5. Cov impurities thiab endotoxins: Rau kev tshawb fawb- qib peptides, purity (Ntau dua lossis sib npaug li 95% lossis siab dua), hom ntsev, cov kuab tshuaj seem thiab endotoxin qib yuav tsum tau txhais kom meej kom tsis txhob ua yuam kev ua rau muaj cov kab mob sib kis rau DSIP nws tus kheej.
FAQ
Q: Dab tsi specifications koj muab?
A: Peb tuaj yeem muab cov hmoov lyophilized nrog purity Ntau dua lossis sib npaug li 99.68%, txhawb nqa thib peb-kev xeem (xws li Chromate/Janoshik, thiab lwm yam).
Q: Yuav ua li cas kom paub meej tias tus kheej molecular?
A: Sib piv cov theoretical monoisotope loj siv LC-MS/ESI; nws yuav tsum yog 848.33 Da ([M+H]+≈849.34), nrog rau tag nrho chromatogram/mass spectrum txuas.
Q: Yuav ua li cas reconstitute thiab npaj?
A: Peb pom zoo kom rov kho dua nrog BAC dej rau 1-5 mg / mL, pH 4-6. Tsis txhob muaj zog alkalis. Txhawm rau kom tsis muaj menyuam, lim los ntawm 0.22 μm lim ua ntej siv.
Q: Cia thiab ruaj ntseg ceev faj?
A: Lyophilized cov khoom yuav tsum tau qhuav ntawm −20 degree, tiv thaiv los ntawm lub teeb, thiab aliquoted kom tsis txhob rov khov dua -thaw cycles. Aqueous daws yuav tsum tau khaws cia ntawm 4℃rau tsawg dua los yog sib npaug rau 1 lub lis piam thiab −20℃rau Tsawg tshaj los yog sib npaug rau 3 lub hlis, saib xyuas kom tiv thaiv Trp oxidation.
Q: Koj puas tuaj yeem hloov kho?
A: Yog, peb tuaj yeem hloov kho. Ntxiv nrog rau DSIP peptide hmoov, peb tuaj yeem kho cov vials hauv ntau qhov tshwj xeeb. Tsis tas li ntawd, peb tuaj yeem kho peptides raws li cov amino acid sequences.
Q: Cov qib endotoxin puas tuaj yeem tswj tau?
A: Peb tswj cov qib endotoxin thaum lub sij hawm tsim khoom raw. Tsawg EU specifications muaj (rau kev tshawb fawb siv xwb).
Q: Qhov loj me thiab kev xa khoom / shipping?
A: Haum rau mg-multigram kom muaj nuj nqis, nrog tus qauv xa hauv 4-6 hnub ua haujlwm.
Shaanxi Medibridge tsim cov khoom peptide rau cov tsev kawm ntawv qib siab thiab cov chaw tshawb fawb thoob ntiaj teb. Peb muab lyophilizedDSIP peptide hmoovrau kev tshawb fawb siv, lees paub ntawm ntau dua los yog sib npaug rau 99.72% purity thiab nrog rau tag nrho COA. Cia siab tias lub sijhawm ua cov khoom lag luam muaj kev vam meej, ntim khoom ruaj ntseg, kev txhawb nqa sai, thiab cov khoom lag luam zoo ib yam. Peb xa khoom thoob ntiaj teb. Rau cov lus hais lossis cov qauv, hu rau hi@medibridgeapi.com lossis WhatsApp +44 07548632075. Kev tshawb fawb siv nkaus xwb.
Cim npe nrov: Tuam Tshoj dsip peptide hmoov manufacturers, lwm tus neeg, Hoobkas
