Melanotan hmoov (Afamelanotide, NDP- -MSH; CAS 75921-69-}6) yog ib qho hluavtaws analog ntawm -MSH tsim los rau kev tshawb fawb ntawm melanogenesis thiab MC1R signaling. Cov peptide nta N-terminal acetylation thiab C-terminal amidation, nrog rau kev hloov pauv tseem ceeb ntawm norleucine (Nle) thiab D-phenylalanine uas txhim khu kev ruaj ntseg, ua rau nws zoo rau kev sim hauv vitro thiab kev tshawb fawb pigment hauv cellular lossis tsiaj qauv.
Cov khoom lag luam yog tsim los ntawm cov khoom siv -theem peptide synthesis (SPPS) thiab muaj xws li cov khoom siv raw lossis raws li kev hloov pauv lyophilized vials. Raws li kev thov, peb muab cov kev pabcuam kuaj ntxiv nrog rau kev ua kom huv, cov ntsiab lus peptide, endotoxin, thiab cov kuab tshuaj seem. Raws li Tuam Tshoj -raws li cov chaw tsim khoom melanotan, Medibridge Biotech txhawb kev txiav txim ntau nrog cov nqi lag luam wholesale, hloov kho vial hloov tau yooj yim, thiab npaj tau- rau- nkoj khoom.
Yog tias koj xav tau qhov hloov tshiab ntawm peb qhov kev tshaj tawm tshiab, lossis xav tau los ntawm Made in China raw cov ntaub ntawv ncaj qha los ntawm peb lub Hoobkas, thov hu rau peb kom paub meej..
COA
|
|
||
|
Khoom npe |
CAS Nr |
Batch Number |
|
Melanotan |
75921-69-6 |
MB2509101102 |
|
Hnub tim tsim khoom |
Hnub Soj Ntsuam |
Hnub Kawg |
|
2025-09-10 |
2025-09-11 |
2027-09-09 |
|
Qauv Qty Base |
Ntim |
Txoj Kev Xeem |
|
50.42 KWG |
100GS / lub raj mis |
HPLC |
|
Yam khoom |
Txuj |
Cov txiaj ntsig |
|
Purity |
Ntau dua lossis sib npaug li 98% |
99.47% |
|
Peptide Assay |
Ntau dua lossis sib npaug li 80% |
89.80% |
|
Loj Spectrum |
1646.85 |
1646.85 |
|
Solubility |
Soluble hauv dej |
Ua raws |
|
Clarity thiab xim ntawm kev daws |
Ntshiab thiab tsis muaj xim |
Ua raws |
|
ntsev |
<5.0% |
1.79% |
|
Dej |
Tsawg dua lossis sib npaug li 7.0% |
2.03% |
|
Residual Solvent: Methanol |
||
|
Tsawg dua lossis sib npaug li 0.3% |
0.0055% |
|
|
Cov tshuaj acetonitrile |
Tsawg dua lossis sib npaug li 0.041% |
0.031% |
|
Methylene Chloride |
Tsawg dua lossis sib npaug li 0.06% |
0.029% |
|
N,N{0}}Dimethylformamide |
Tsawg dua lossis sib npaug li 0.088% |
N.D. |
|
Triethylamine |
Tsawg dua lossis sib npaug li 0.032% |
N.D. |
|
Tert -butyl methyl ether |
Tsawg dua los yog sib npaug li 0.5% |
0.216% |
|
Endotoxin |
Tsawg dua lossis sib npaug li 0.5 EU / mg |
Ua raws |
|
Microbial txwv |
Tag nrho cov kab mob aerobic<100 CFU/g Tag nrho cov poov xab & pwm<50 CFU/g |
<50 CFU/g <10 CFU/g |
|
Cia |
Khaws rau hauv qhov chaw tsaus thiab txias qhuav (-20 txog 8 degree) |
|
|
Xaus |
Cov batch ua raws li IN-HOUSE tus qauv |
|
|
|
||
Khoom Description
|
Daim ntawv |
Qauv Order |
Specification |
|
Cov hmoov nyoos |
1 g |
Purity yog NLT 99% |
|
Vials |
10 vials |
3ml / 5ml / 7ml / 15ml vials thiab lwm yam. |
Phau ntawv Snapshot
Kev tshawb fawb ntawm Afamelanotide (Melanotan-1) qhia txog kev xaiv MC1R agonism nrog cAMP-MITF ua kom muaj zog, nce - tswj TYR/TRP1/DCT thiab kev tsis ncaj ncees rau eumelanin. Thoob plaws cov qauv, pigmentation nce taug qab nrog cov teeb liab ntawm kev tiv thaiv kev tiv thaiv, nrog rau tsawg dua UV-induced DNA- cov cim kev puas tsuaj. Clinically, ib qho kev cog qoob loo tau raug siv hauv EPP txhawm rau ua kom lub teeb pom kev zoo thiab txhim kho tus neeg mob- tau tshaj tawm cov txiaj ntsig; kam rau ua yog tsuas yog dermatological / GI thiab tswj tau nrog koob tshuaj. Cov chaw tshawb fawb tam sim no ntawm kev siv tshuab, photobiology, oxidative-stress crosstalk, thiab kev rov ua dua tshiab.
Kev Tshawb Fawb Txog Kev Tshawb Fawb
Melanotan hmoov ua dab tsi?
Melanotan-1 ua zoo li "pib teeb liab" ntawm melanocytes: nws koom nrog MC1R, nudging hlwb los tsim thiab xa melanin-melanin "umbrellas" uas tob zuj zus thiab txawm tias tawv nqaij tawv thaum sib koom cov khoom hauv qab hnub ci. Nrog MT-1, pigmentation tuaj yeem txhim kho nrog qis UV thiab nrawm rau hauv qhov chaw raug. Hauv EPP, ib qho kev cog qoob loo nce qhov mob ntau ntxiv - lub sijhawm lub teeb dawb thiab lub neej zoo, yuav muaj kev ntxiv melanin ntxiv rau cov tshuaj antioxidant, DNA-kev puas tsuaj- teb, thiab cov tshuaj tiv thaiv kab mob.
PK circadian suab
Afamelanotide, tus MC1R agonist, feem ntau qhia tau hais tias qhov nce ntxiv -ces - poob qhov profile hauv lub rooj zaum qauv. Tom qab kev tswj hwm, qib nce mus rau qhov siab tshaj plaws ua ntej tapering raws li kev faib thiab kev tshem tawm. Cov schematic hauv qab no sketches xya-hnub sim lub voj voog thiab sib piv ib zaug - koob tshuaj tiv thaiv kev tswj hwm- tso tawm cov qauv: lub qub peaks ntxov thiab poob mus rau ib lub trough; lub tom kawg ua rau ib tug dav dav toj siab ua ntej easing down. Lub sijhawm tiag tiag sib txawv nrog rau hom, matrix (plasma / daim ntaub), koob tshuaj thiab lub tsheb, kev soj ntsuam rhiab heev, thiab kev tsim.
Cov Lus Qhia Txog Kev Tshawb Fawb Tshiab
Kev tshawb nrhiav Vitiligo Repigmentation
Afamelanotide tam sim no tau raug sim hauv vitiligo ua ib qho ntxiv - rau nqaim -band UVB. Lub tswv yim yog yooj yim: MT-1 "primes" melanocytes, thaum NB-UVB muab lub teeb liab ua kom muaj zog, yog li kev rov ua dua tuaj yeem pib sai dua thiab nthuav dav dua li lub teeb ib leeg. Tom qab cov kev tshawb fawb me me qhia tau hais tias sai dua, kev nce siab dua -tshwj xeeb tshaj yog nyob rau hauv cov tawv nqaij tsaus nti- ib qho loj, ntau- cheeb tsam Phase III qhov kev pab cuam pib piv cov combo nrog NB-UVB monotherapy siv cov txiaj ntsig zoo li T-VASI. Kev nyab xeeb tau tswj tau hauv kev ua haujlwm ua ntej (feem ntau yog dermatological / GI). Cov kev sim no yuav qhia seb peptide + lub teeb mus kom ze tuaj yeem xa cov khoom siv ruaj khov, tag nrho lub cev rov ua dua tshiab hauv kev saib xyuas niaj hnub.
Ntau-Txoj Kev Nyuaj Siab- Kev Tswj Xyuas Kev Tshawb Fawb
Hauv 2023 CUV156 kev tshawb fawb soj ntsuam tso tawm los ntawm CLINUVEL, cov kws tshawb fawb tau soj ntsuam qhov cuam tshuam ntawm afamelanotide ntawm UV-induced DNA puas hauv XP-C cov neeg mob. Vim tias tsis muaj DNA kho cov txheej txheem, cov tib neeg uas muaj XP muaj kev pheej hmoo rau mob qog noj ntshav tom qab hnub raug tshav. Txoj kev tshawb no tsom mus rau kev ntsuam xyuas kev puas tsuaj ntawm daim tawv nqaij thiab seb afamelanotide tuaj yeem txhim kho qhov kev qhia ntawm DNA kho cov cim.
Kev tshawb pom pom tias afamelanotide txo qis cov cim ntawm UV- cuam tshuam txog DNA kev puas tsuaj, xws li -H2AX thiab CPD, thiab nce kho cov teeb liab hauv qee cov neeg mob. Tshaj li 10-hnub kev kho mob, tsis muaj qhov tshwm sim tsis zoo tshwm sim, thiab pom kev puas tsuaj ntawm daim tawv nqaij tau txo qis. Cov txiaj ntsig no qhia tias afamelanotide tuaj yeem qhib MC1R txoj hauv kev, txhawb nqa DNA kho thiab tiv thaiv cellular.
Raws li cov kws tshaj lij los ntawm British Association of Dermatologists, afamelanotide muab cov qauv rau kev txhim kho DNA kho thiab tawv tawv tawv hauv XP-C cov neeg mob.
FAQ
Q: Koj noj Melanotan-1 li cas?
A: Clinically: ib leeg-siv 16 mg biodegradable implant tso subcutaneously ze ntawm lub iliac crest los ntawm cov neeg ua haujlwm cob qhia, feem ntau hais txog txhua txhua 2 lub hlis thaum lub caij ci rau EPP.
Tsis txhob txhaj tshuaj tiv thaiv tus kheej lossis siv online "tanning" khoom; txuas ntxiv kev tiv thaiv hnub ci raws li koj tus kws kho mob qhia.
Q: Lub neej ib nrab ntawm Melanotan-1 yog dab tsi?
A: Lub peptide lub plasma ib nrab-lub neej yog luv luv (kwv yees li 1 teev), tab sis cov implants muab kev tso tawm ntev li ob peb hnub; melanin induction thiab kev kho mob tshwm sim feem ntau nyob rau lub lis piam.
Q: Thaum twg Melanotan thawj zaug siv?
A: Lub tswv yim thiab kev sib txuas tau tshwm sim hauv xyoo 1980s; kev tshawb fawb txog tib neeg thaum ntxov tau tshwm sim hauv 1990s. MT-1 tau txais kev pom zoo rau EPP (EU ua ntej, tom qab US).
Q: Vim li cas ho tsis "Melanotan" FDA-pom zoo rau tanning?
A: Vim tias cov tshuaj pleev xim pleev xim tsis muaj qhov pom zoo txaus ntshai-cov txiaj ntsig profile thiab cov ntaub ntawv kev nyab xeeb / zoo. Tsuas yog MT‑1 (EPP) thiab MT‑2 (HSDD) yog cov ntawv pom zoo; "melanotan" muag rau tanning tseem tsis pom zoo thiab pheej hmoo.
Q: Qhov txawv ntawm Melanotan-1 thiab Melanotan-2 yog dab tsi?
A: MT‑1 (afamelanotide) feem ntau tsom rau MC1R hauv melanocytes los txhawb eumelanin; MT‑2 (bremelanotide) yog xaiv tsawg (MC1/3/4/5), nrog rau cov teebmeem hauv nruab nrab.
|
Feature |
MT-1 (Afamelanotide) |
MT-2 (Bremelanotide) |
|
Receptor profile |
Feem ntau MC1R |
MC1/3/4/5 (nrog rau MC4R) |
|
Pom zoo siv |
EPP: nce lub sij hawm tsis muaj mob |
HSDD (Cov poj niam premenopausal) |
|
Dosing daim ntawv |
16 mg SC implant (los ntawm HCP) |
1.75 mg SC txhaj tshuaj PRN |
|
Common AEs |
xeev siab, qaug zog, implant-site tshuaj, hyperpigmentation / nevus darkening |
xeev siab, ntuav, ntuav, hloov pauv BP, mob taub hau |
Tsim Melanotan?
Synthetic melanocortin analogues tau tsim nyob rau xyoo 1980 los ntawm University of Arizona cov kws tshawb fawb (xws li Victor Hruby, Mac Hadley thiab cov npoj yaig), ua rau MT‑1 thiab tom qab MT‑2.
Melanotan hmoovtam sim no qhia tau hais tias muaj zog cog lus nyob rau hauv pigmentation kev tshawb fawb, photoprotection qauv, thiab kev tshawb fawb repigmentation (xws li, vitiligo) nyob rau hauv lub chaw kuaj mob. Yog tias koj tab tom nrhiav rau lub siab - cov chaw tsim khoom peptide zoo tau cog lus los tsim kev sib koom tes ntev - thiab ruaj khov, thov hu rau peb ntawm: hi@medibridgeapi.com.
Cim npe nrov: Melanotan hmoov, Tuam Tshoj melanotan hmoov manufacturers, lwm tus neeg, Hoobkas
