Emtricitabine APIyog ib qho tshuaj tiv thaiv kab mob uas feem ntau siv los kho tus kab mob HIV (tus kab mob tiv thaiv kab mob tib neeg) thiab, qee zaum, rau kab mob siab B. Nws belongs rau cov chav kawm ntawm cov tshuaj hu ua nucleoside reverse transcriptase inhibitors (NRTIs). Nws ua haujlwm los ntawm kev tiv thaiv HIV los ntawm kev rov ua dua nws cov khoom siv caj ces los ntawm kev rov qab transcriptase enzyme, yog li tiv thaiv tus kab mob los ntawm kev sib npaug.
Nws yog ib tug nucleoside analogue uas ua raws li lub tsev blocks ntawm DNA. Thaum tus kab mob sim rov ua dua nws cov khoom siv caj ces, cov khoom no tau muab tso rau hauv cov kab mob DNA loj zuj zus. Qhov kev koom ua ke no cuam tshuam lub peev xwm ntawm tus kab mob mus txuas ntxiv, tiv thaiv kev kis kab mob ntxiv. Emtricitabine ua haujlwm los ntawm inhibiting reverse transcriptase, ib qho enzyme uas HIV xav kom rov ua dua. Los ntawm thaiv cov enzyme no, cov khoom no tiv thaiv kev hloov pauv ntawm tus kab mob RNA rau hauv DNA, yog li cuam tshuam cov kab mob sib kis thiab txo cov kab mob hauv lub cev.
Shaanxi Medibridge Biotech Co., Ltd. tsom rau kev muab cov khoom siv tshuaj raw khoom thiab kev tshawb fawb- siv cov khoom sib txuas. Peb txhawb cov neeg siv khoom nrog kev ruaj khov zoo, kev sib txuas lus meej meej, kev xaiv ntim tau yooj yim, thiab cov ntaub ntawv - cuam tshuam txog kev txhawb nqa rau theem sib txawv.
COA
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Khoom npe |
CAS Nr |
Batch Number |
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Emtricitabine API |
143491-57-0 |
MB2606100214 |
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Hnub tim tsim khoom |
Hnub Soj Ntsuam |
Hnub Kawg |
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2026/6/10 |
2026/6/11 |
2028/6/10 |
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Qauv Qty Puag |
Ntim |
Txoj Kev Xeem |
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25 KGS |
5KG / nruas |
HPLC |
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Yam khoom |
Txuj |
Cov txiaj ntsig |
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Qhov tshwm sim |
dawb kom tawm -dawb hmoov |
Ua raws |
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Yam khoom (HPLC) - Tag nrho impurity |
Tsawg dua los yog sib npaug li 0.5% |
0.2% |
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Lwm yam tshuaj (HPLC) - Max ib qho impurity |
Tsawg dua lossis sib npaug li 0.1% |
0.06% |
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tsw |
Yam ntxwv |
Ua raws |
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Poob Thaum Qhuav |
NMT 0.1% |
0.12% |
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Residue ntawm Ignition |
0.5% NMT |
0.09% |
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Hnyav Hlau |
NMT 10 ppm |
Ua raws |
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Raws li |
NMT 0.1 ppm |
Ua raws |
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Pb |
NMT 0.1 ppm |
Ua raws |
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Cd |
NMT 0.1 ppm |
Ua raws |
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Assay |
Ntau dua lossis sib npaug li 99% |
99.89% |
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Xaus |
Cov batch ua raws li IN-HOUSE tus qauv |
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Ntsiab Molecular Mechanisms
Competitive Inhibition thiab DNA Chain Termination
Kev sib tw substrate: FTC-TP ze ze ua rau lub ntuj substrate deoxycytidine triphosphate (dCTP) thiab sib tw khi rau qhov chaw nquag ntawm HIV-1 thim rov qab transcriptase (RT) lossis HBV DNA polymerase.
Elongation Blockade (Chain Termination): Vim tsis muaj 3'-hydroxyl (-OH) pab pawg ntawm oxathiolane nplhaib ntawm FTC, ib zaug FTC-TP tau koom ua ke rau hauv cov kab mob loj hlob ib leeg-stranded DNA, nws tiv thaiv kev tsim ntawm cov saw hlau tom qab phosphate, 3. tshem tawm cov kab mob DNA synthesis.
Ntev Intracellular Ib Nrab -Lub Neej thiab Tsawg Mitochondrial Toxicity
High Selectivity Index: Piv rau thawj - tiam NRTIs (xws li AZT thiab ddI), FTC-TP nthuav tawm tsis tshua muaj affinity rau tib neeg cellular DNA polymerases , thiab (tshwj xeeb tshaj yog qhia negligible inhibition tiv thaiv Pol , uas yog lub luag hauj lwm rau mitochondrial DNA replication). Yog li ntawd, nws qhia qhov tsawg kawg nkaus mitochondrial toxicity.
Extended Intracellular Ib nrab-Lub Neej: FTC-TP muaj qhov txuas ntxiv nyob rau hauv ib nrab- lub neej ntawm ntau dua 39 teev hauv tib neeg cov lymphocytes, muab lub hauv paus muaj zog molecular pharmacology rau ib zaug-txhua hnub (QD) kev tswj hwm thiab kev tiv thaiv ruaj khov hauv Pre-Kev Tiv Thaiv Kab Mob).
Antiviral Mechanism: Intracellular Activation thiab Chain Termination
Tom qab nkag mus rau hauv lub cell, emtricitabine (FTC) yog phosphorylated los ntawm tus tswv tsev enzymes rau nws daim ntawv nquag, emtricitabine 5'-triphosphate. Cov metabolite no sib tw nrog lub ntuj substrate deoxycytidine triphosphate rau HIV-1 thim rov qab transcriptase. Thaum muab tso rau hauv cov kab mob DNA, nws tiv thaiv cov saw txuas ntxiv. Kev tshawb fawb yog li no txiav txim siab ob qho tib si raug rau niam txiv compound thiab tsim ntawm nws cov active intracellular metabolite.
Emtricitabine kuj muaj kev ua haujlwm tiv thaiv kab mob siab B (HBV), tab sis nws tsis raug pom zoo raws li kev sawv cev-ib leeg kho rau tus kab mob siab B. Nyob rau hauv cov neeg uas muaj kab mob HIV/HBV coinfection, txwv tsis pub ib qho emtricitabine- muaj cov tshuaj tiv thaiv yuav ua raws li kev mob siab rau tus kab mob siab B.
Resistance thiab Hla -Resistance Research
M184V thiab M184I hloov pauv hauv HIV-1 thim rov qab transcriptase yog lub hauv paus rau kev tshawb fawb emtricitabine resistance. Lawv kuj tseem muaj feem cuam tshuam rau kev hla -kev tiv thaiv nrog lamivudine, ib qho zoo sib xws nucleoside analogue. Kev ua haujlwm ntawm emtricitabine-muaj cov txheej txheem tiv thaiv kab mob HIV tsis tuaj yeem raug xam los ntawm API ib leeg; kev txhais lus yuav tsum muaj tus kab mob genotype, phenotypic susceptibility thaum muaj, thiab cov kev ua ntawm lwm yam tshuaj nyob rau hauv lub regimen. Cov yam ntxwv no ua rau emtricitabine muaj txiaj ntsig rau kev kawm txog kev xaiv tshuaj tiv thaiv kab mob thiab cov tswv yim ua ke.
Pharmacokinetics thiab lub raum ua haujlwm
Emtricitabine ua rau muaj kev cuam tshuam rau lub cev tom qab kev tswj hwm qhov ncauj, muaj cov ntshav plasma protein tsawg, thiab tshem tawm feem ntau los ntawm ob lub raum. Txo lub raum ua haujlwm hloov nws cov tshuaj pharmacokinetics thiab yuav tsum tau txiav txim siab thaum ua tiav- cov khoom tsim. Qhov no yog ib qho tseem ceeb tshwj xeeb rau kev kho - koob tshuaj ua ke: lawv cov khoom yuav muaj cov kev cai sib txawv rau kev siv raum tsis zoo, yog li kev hloov kho muaj feem xyuam rau ib qho -tus neeg sawv cev emtricitabine cov khoom lag luam tsis tuaj yeem siv rau cov khoom sib xyaw ua ke.
Kev txiav txim siab txog kev nyab xeeb thiab kev tshawb fawb ciam teb
Kev nyab xeeb profile ntawm emtricitabine yuav tsum tau txhais nyob rau hauv cov ntsiab lus ntawm cov khoom tiav thiab tag nrho cov tshuaj tiv thaiv kab mob. Ib qho mob hnyav ntawm tus kab mob siab B tom qab txiav tawm yog ib qho kev txhawj xeeb tshwj xeeb rau cov neeg uas muaj HIV / HBV coinfection. Hloov pauv, kev pheej hmoo cuam tshuam nrog lwm yam ntawm cov khoom sib xyaw ua ke yuav tsum tsis txhob raug ntaus nqi rau emtricitabine nws tus kheej. Kev tshawb fawb API yuav tsum paub qhov txawv ntawm cov khoom ntawm tus kheej los ntawm kev sib cuam tshuam hauv kev tsim thiab cov txiaj ntsig tau pom hauv kev siv tshuaj kho mob.
FAQ
API sawv cev rau dab tsi hauv khw muag tshuaj?
Hauv khw muag tshuaj thiab kev lag luam kho mob, API sawv cev rau Cov Khoom Siv Tshuaj.
emtricitabine yog dab tsi?
Emtricitabine yog ib hom tshuaj tiv thaiv kab mob uas siv los kho thiab tiv thaiv tib neeg kev tiv thaiv kab mob HIV (HIV).
Leej twg yog tus tshaj 10 API tuam ntxhab nyob hauv lub ntiaj teb?
Cov khoom siv tshuaj zoo tshaj plaws (API) cov tuam txhab hauv ntiaj teb suav nrog cov thawj coj loj hauv ntiaj teb biopharmaceutical thiab cov kws tsim khoom tshwj xeeb / generic API.
API hauv tshuaj yog dab tsi?
Hauv kev lag luam kws tshuaj, API sawv cev rau Cov Khoom Siv Tshuaj Siv Tshuaj.
Cim npe nrov: Tuam Tshoj emtricitabine api manufacturers, lwm tus neeg, Hoobkas
