Empagliflozin hmoovyog ib qho tshwj xeeb xaiv sodium -glucose cotransporter 2 (SGLT2) inhibitor. Raws li kev tsim qauv, nws siv C-glycosidic daim ntawv cog lus los txuas lub nplhaib uas muaj ntxhiab thiab glycosyl pawg, qhov sib txawv tseem ceeb ntawm cov tsoos O-glycosides. Qhov C-glycosidic daim ntawv cog lus no muab kev ruaj ntseg enzymatic heev, txhim kho cov tshuaj tiv thaiv rau acidic ib puag ncig thiab ua rau cov enzymatic degradation, ua rau muaj zog metabolic stability thiab ib nrab ntev -lub neej nyob rau hauv lub plab thiab cov hlab ntsha. Nws cov tub ntxhais yog lub nplhaib hloov benzene, nrog cov tshuaj chlorine atoms thiab ethoxybenzyl substituents ntawm lub nplhaib aromatic sab chains, muab cov molecule nruab nrab hydrophobicity thiab ua rau nws yooj yim rau nkag mus rau cell membranes thiab khi rau lub hom phiaj proteins.
Tsis tas li ntawd, lub nplhaib tetrahydropyranose ntawm Empagliflozin muaj ntau lub chaw chiral thiab hydroxyl pawg, ua rau nws khi rau SGLT2 transporter ntau cov kev taw qhia thiab xaiv. Nws yog ruaj khov nyob rau hauv nws daim ntawv crystalline, muaj me ntsis solubility, thiab feem ntau yog muaj nyob rau hauv lub qhov ncauj ntsiav tshuaj nrog rau qhov ncauj zoo heev nqus. Los ntawm kev tsim qauv ntawm nws cov yam ntxwv stereochemical thiab kev hloov pauv, cov kws tshawb fawb tau txhim kho nws cov bioavailability thiab kev xaiv inhibitory muaj peev xwm thaum tswj hwm qhov sib npaug ntawm lipophilicity thiab hydrophilicity, ua Empagliflozin yog ib qho ntawm cov qauv zoo tshaj plaws thiab cov neeg sawv cev xaiv cov tebchaw tam sim no ntawm SGLT2 inhibitors.
Shaanxi Medibridge Biotech Co., Ltd. tsom rau kev muab cov khoom siv tshuaj raw khoom thiab kev tshawb fawb- siv cov khoom sib txuas. Peb txhawb cov neeg siv khoom nrog kev ruaj khov zoo, kev sib txuas lus meej meej, kev xaiv ntim tau yooj yim, thiab cov ntaub ntawv - cuam tshuam txog kev txhawb nqa rau theem sib txawv.
COA
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Khoom npe |
CAS Nr |
Batch Number |
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Empagliflozin hmoov |
864070-44-0 |
MB2606130045 |
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Hnub tim tsim khoom |
Hnub Soj Ntsuam |
Hnub Kawg |
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2026/6/13 |
2026/6/15 |
2028/6/15 |
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Qauv Qty Puag |
Ntim |
Txoj Kev Xeem |
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100 KGS |
25KG / nruas |
HPLC |
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Yam khoom |
Txuj |
Cov txiaj ntsig |
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Qhov tshwm sim |
Dawb hmoov |
Ua raws |
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tsw |
Yam ntxwv |
Ua raws |
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Assay |
Ntau dua lossis sib npaug li 98.0% |
98.52% |
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Particle Loj |
100% dhau 80 mesh |
Ua raws |
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Moisture |
<5.0% |
Ua raws |
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Tshauv Ntsiab Lus |
<4.0% |
Ua raws |
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Solvent Residue |
Eur. Pharm |
Ua raws |
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Total Heavy Metals |
<10 ppm |
Ua raws |
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Arsenic |
<1.0 ppm |
Ua raws |
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Coj |
<1.0 ppm |
Ua raws |
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Mercury |
<0.5 ppm |
Ua raws |
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DDT |
<0.2ppm |
Ua raws |
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E. Coli |
Tsis zoo |
Tsis zoo |
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GMO Status |
Ua raws |
GMO Dawb |
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Irradiation |
Ua raws |
Irradiation Dawb |
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Xaus |
Cov batch ua raws li IN-HOUSE tus qauv |
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Primary Molecular Mechanism
Lub raum SGLT2 Inhibition
SGLT2 reabsorbs ntau ntawm cov kua nplaum uas lim hauv lub raum lub tubule. Empagliflozin inhibits qhov kev thauj mus los no, txo qis lub raum pib rau cov piam thaj thiab ua rau cov zis tso zis ntau ntxiv. Nws kuj tseem txo cov sodium reabsorption, ua kom sodium xa mus kom deb ntawm nephron. Cov kev cuam tshuam txuas no muab cov ntsiab lus pib rau kev tshawb fawb txog kev tuav cov piam thaj, osmotic diuresis, kev tawm tswv yim tubuloglomerular, thiab intraglomerular siab. accessdata.fda.gov
Kev ntsuam xyuas thauj yuav tsum paub qhov txawv ncaj qha SGLT2 inhibition los ntawm kev hloov pauv hauv qab los ntawm kev hloov pauv piam thaj lossis sodium muaj. Cov kev tswj tau muaj txiaj ntsig suav nrog kev thauj mus los- nthuav qhia thiab tswj cov hlwb, concentration- nyob ntawm kev ntsuas kev nce siab, kev ntsuas kev muaj peev xwm, thiab kev pom zoo ntawm cov khoom sib xyaw ua ke.
Lub raum thiab Metabolic Physiology
Empagliflozin muaj ib txoj hauv kev los tshuaj xyuas seb yuav hloov lub raum qabzib reabsorption cuam tshuam li cas rau lub cev dav dav. Cov ntsiab lus ntawm kev tshawb fawb yuav suav nrog cov piam thaj hauv zis, zis ntim, tuav sodium, lub cev - kua dej sib npaug, thiab lub raum ua haujlwm dhau sijhawm. Cov piam thaj- txo qis cov lus teb yog nyob ntawm ib feem ntawm cov kua qabzib lim dej: cov khoom lag luam sau tseg tias cov piam thaj tso zis tso zis poob qis thaum lub raum ua haujlwm qis, txawm tias qhov ua rau empagliflozin tuaj yeem nce ntxiv.
Qhov kev sib txawv no tseem ceeb thaum txhais qhov kev sim. Cov tshuaj plasma concentration, qabzib-kev kuaj mob thauj mus los, thiab tag nrho- lub raum physiological teb teb cov lus nug sib txawv thiab yuav tsum tsis txhob siv sib hloov.
Kev Tshawb Fawb Txog Kev Mob plawv thiab raum
Empagliflozin tau kawm nyob rau hauv cov kev pab cuam kho mob loj thoob plaws hom 2 mob ntshav qab zib mellitus nrog cov kab mob plawv, plawv tsis ua hauj lwm, thiab mob raum. Cov ntawv sau npe hauv Asmeskas suav nrog cov cim qhia txog kev mob plawv thiab lub raum rau cov neeg teev tseg. Cov txiaj ntsig kho mob no tsim cov txiaj ntsig ntawm cov khoom siv tshuaj ntsuam xyuas thiab kev kawm txog kev tswj hwm; lawv tsis tsim kom muaj cov hmoov uas tsis muaj ntaub ntawv yuav ua rau tib yam raug lossis tshwm sim.
Rau kev tshawb fawb siv tshuab, ib lo lus nug tseem ceeb yog qhov ntsuas lub plawv lossis lub raum teb raws li lub raum cov piam thaj thiab sodium thauj, thiab ntau npaum li cas cuam tshuam nrog kev hloov pauv hauv cov ntim ntim, hemodynamics, lossis cov ntaub so ntswg. Cov txheej txheem thib ob uas tau hais tseg yuav tsum raug kuaj ncaj qha es tsis suav los ntawm qhov tshwm sim ib leeg.
Metabolism thiab Transporter Interactions
Tib neeg cov metabolism cuam tshuam nrog glucuronidation, nrog UGT2B7, UGT1A3, UGT1A8, thiab UGT1A9 cuam tshuam hauv vitro. Daim ntawv lo qhia txog peb glucuronide conjugates thiab tshaj tawm tias tsis muaj metabolite loj hauv plasma. Nws kuj piav qhia txog empagliflozin raws li lub substrate ntawm P-glycoprotein thiab BCRP, thaum qhia tias inhibition ntawm loj CYP450 enzymes tsis xav tau ntawm kev kho mob cuam tshuam. accessdata.fda.gov
Qhov profile no ua rau empagliflozin cuam tshuam rau UGT metabolism, thauj, thiab tshuaj - kev tshawb fawb txog kev sib cuam tshuam. Nyob rau hauv vitro transporter cov txiaj ntsig yuav tsum txawm li cas los xij yuav tsum tau muab txhais ua ke nrog kev ntsuas qhov siab dawb thiab kev tswj hwm zoo tsim nyog; substrate xwm txheej ib leeg tsis tsim kom muaj kev sib tham tseem ceeb hauv tsev kho mob.
Metabolism thiab Transporter Interactions
Tib neeg cov metabolism cuam tshuam nrog glucuronidation, nrog UGT2B7, UGT1A3, UGT1A8, thiab UGT1A9 cuam tshuam hauv vitro. Daim ntawv lo qhia txog peb glucuronide conjugates thiab tshaj tawm tias tsis muaj metabolite loj hauv plasma. Nws kuj piav qhia txog empagliflozin raws li lub substrate ntawm P-glycoprotein thiab BCRP, thaum qhia tias inhibition ntawm loj CYP450 enzymes tsis xav tau ntawm kev kho mob cuam tshuam.
Qhov profile no ua rau empagliflozin cuam tshuam rau UGT metabolism, thauj, thiab tshuaj - kev tshawb fawb txog kev sib cuam tshuam. Nyob rau hauv vitro transporter cov txiaj ntsig yuav tsum txawm li cas los xij yuav tsum tau muab txhais ua ke nrog kev ntsuas qhov siab dawb thiab kev tswj hwm zoo tsim nyog; substrate xwm txheej ib leeg tsis tsim kom muaj kev sib tham tseem ceeb hauv tsev kho mob.
Solubility, Dissolution, thiab Oral Formulation
me ntsis dej solubility ua rau cov qauv kev npaj thiab kev sib cais tseem ceeb rau kev ua haujlwm ntawm tes thiab ntau npaum li cas - kev txhim kho. Ib qho ntshiab concentrated stock yuav precipitate tom qab dilution rau hauv kab lis kev cai nruab nrab, yog li cov nominal npaum li cas ntxiv yuav txawv ntawm cov nyiaj muaj nyob rau hauv lub hlwb. Cov kev tshawb fawb txog kev tsim qauv yuav tsum ntsuas particle- qhov loj me, kev faib tawm, kev sib cais hauv cov xov xwm tsim nyog, sib xyaw thiab cov ntsiab lus sib xws, thiab kev ruaj ntseg hauv pob khoom.
Cov kev hloov pauv uas txhim kho kev sib cais yuav tsum raug ntsuas los ntawm kev ntsuas qhov raug, tsis yog xav tias yuav txhim kho kev ua tau zoo. Ib tus neeg nqa khoom lossis cov txheej txheem ua tiav yuav hloov pauv kev tso tawm, nqus, lossis ruaj khov hauv txoj hauv kev uas yuav tsum tau kuaj rau cov khoom tshwj xeeb.
FAQ
Dab tsi yog lub hom phiaj lom neeg lub hom phiaj thiab cov txheej txheem ntawm kev ua rau Empagliflozin?
Empagliflozin yog ib qho kev xaiv ntau yam inhibitor ntawm sodium -glucose cotransporter 2 (SGLT2) uas thaiv lub raum qabzib reabsorption nyob rau hauv proximal lub raum tubules.
Dab tsi yog qhov tseem ceeb ntawm kev tshawb fawb txog kev siv tshuaj lom neeg rau Empagliflozin Powder?
Nws tau tshawb xyuas dav hauv cov qauv kab mob metabolic, mob ntshav qab zib nephropathy, plawv tsis ua haujlwm, tiv thaiv kab mob plawv, thiab kev tshawb fawb cellular bioenergetics.
Yuav ua li cas Empagliflozin Powder yuav yaj rau ntawm tes-raws li kev soj ntsuam hauv vitro?
Nws yuav tsum tau yaj nyob rau hauv qib siab -qib DMSO los npaj cov tshuaj npaj ua ntej ua ntej serial dilution rau hauv aqueous kab lis kev cai media.
Dab tsi yog qhov kev pom zoo ntev - lub sijhawm khaws cia rau Empagliflozin Powder?
Cov hmoov yuav tsum khaws cia rau ntawm -20C hauv qhov chaw qhuav, tiv thaiv lub teeb kom ntseeg tau tias muaj tshuaj lom neeg.
Cim npe nrov: Tuam Tshoj empagliflozin hmoov manufacturers, lwm tus neeg, Hoobkas
